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TranscriptomicsEfficient engineering of human and mouse primary cells using peptide-assisted genome editing
Simple and efficient delivery of CRISPR genome editing systems in primary cells remains a major challenge. Here, we describe an engineered Peptide-Assisted Genome Editing (PAGE) CRISPR-Cas system for rapid and robust editing of primary cells. PAGE couples a cell-penetrating Cas protein with a cell-p...
ORGANISM(S): Homo sapiens 
2023-03-20 | GSE223805 | GEO
ProteomicsIntrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity
In development, pioneer transcription factors access silent chromatin to reveal lineage-specific gene programs. The structured DNA-binding domains of pioneer factors have been well characterized, but whether and how low-complexity intrinsically disordered regions (IDRs) affect chromatin and control ...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-16 | PXD043586 | Pride
Tcf-1 T-cells L1 Transcription factor Idrs 
GenomicsEfficient engineering of human and mouse primary cells using peptide-assisted genome editing
Efficient engineering of human and mouse primary cells using peptide-assisted genome editing
PRJNA928411 | ENA
UnknownNeuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity.
Not available
S-EPMC7442600 | biostudies-literature
UnknownIntrinsically disordered domain of transcription factor TCF-1 is required for T cell developmental fidelity.
Not available
S-EPMC10919931 | biostudies-literature
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