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TranscriptomicsTranscription profiling of human Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis patients blister cells from skin lesions reveals these consist of cytotoxic T cells annd NK cells
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis; (TEN) are life-threatening adverse drug reactions characterized; by massive epidermal necrosis, in which the specific danger; signals involved remain unclear. Here we show that blister; cells from skin lesions of SJS-TEN primarily consis...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-13727 | biostudies-arrayexpress
TranscriptomicsWhole genome expression data comparison between WT and Cebpg-/- MEFs.
C/EBPβ is an important regulator of oncogene-induced senescence (OIS). Here we show that C/EBPγ, a heterodimeric partner of C/EBPβ whose biological functions are not well understood, inhibits cellular senescence. Cebpg-/- MEFs proliferated poorly, entered senescence prematurely, and expressed a p...
ORGANISM(S): Mus musculus 
2013-06-30 | E-GEOD-47777 | biostudies-arrayexpress
TranscriptomicsInduction of hepatocellular carcinoma through activation of stromal cells in Pdgf-c transgenic mice
Liver cirrhosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet the mechanisms by which cirrhosis predisposes patients to tumorigenesis are not well understood. Transgenic mice expressing platelet-derived growth factor C (Pdgf-c) under the control of the albumin pr...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-38199 | biostudies-arrayexpress
TranscriptomicsPromoter capture-C of primary HepG2 cells
We employed a massively parallel, high resolution Capture-C based method to simultaneously characterize the genome-wide interactions of all human promoters in any cell type. We applied this approach to study the promoter interactome of HepG2 cells (3 biological replicates). We designed a custom Agil...
ORGANISM(S): Homo sapiens 
2019-03-20 | E-MTAB-7144 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of 6 acute hepatitis C patients
Approximately 50% of patients with chronic hepatitis C (CHC) have a sustained virologic response (SVR) to treatment with pegylated interferon (pegINF)-M-NM-1 and ribavirin. Non-response to treatment is associated with constitutively increased expression of IFN-stimulated genes (ISGs) in the liver. T...
ORGANISM(S): Homo sapiens 
2012-06-08 | E-GEOD-38597 | biostudies-arrayexpress
TranscriptomicsInfectious hematopoietic necrosis virus (IHNV) persistence in Sockeye Salmon: effect on brain transcriptome and response to the viral mimic poly(I:C)
To characterise the transcriptional response in brain of Sockeye Salmon (Oncorhynchus nerka) that were persistently infected with infectious hematopoietic necrosis virus (IHNV) and to determine whether carrying the IHNV affects the ability to respond to other immunological challenges we compared the...
ORGANISM(S): Oncorhynchus nerka 
2015-08-10 | E-GEOD-65241 | biostudies-arrayexpress
UnknownAdoption of a biologically-enhanced agricultural management (BEAM) approach in agroecosystems for regenerating soil fertility, improving farm profitability and achieving productive utilization of atmospheric CO<sub>2</sub>.
Not available
S-EPMC11967414 | biostudies-literature
UnknownA recurrent ABCC2 c.2439 + 5G > A variant disturbs mRNA splicing and causes Dubin-Johnson syndrome.
Not available
S-EPMC12275409 | biostudies-literature
TranscriptomicsHepatocytes treated with IFN-alpha or IFN-gamma and acute hepatitis C
This SuperSeries is composed of the following subset Series: GSE38147: Gene expression profiling of primary human hepatocytes treated with IFN-alpha or IFN-gamma GSE38597: Gene expression profiling of 6 acute hepatitis C patients Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-06-08 | E-GEOD-38598 | biostudies-arrayexpress
TranscriptomicsExpression data from C. elegans wild type, hlh-25 mutant and hlh-29 mutant strains
In Caenorhabditis elegans, the six proteins that make up the REF-1 family are HES homologs that act in both Notch dependent and Notch-independent pathways to regulate embryonic events. To further our understanding of how the REF-1 family works to coordinate post-embryonic cellular events, we perfor...
ORGANISM(S): Caenorhabditis elegans 
2016-07-03 | E-GEOD-65417 | biostudies-arrayexpress
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