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ProteomicsThe AMBRA1 E3 ligase adaptor regulates Cyclin D protein stability
Here we describe AMBRA1 as the main regulator of Cyclin D protein degradation. We first identify AMBRA1 as the top candidate in a genome-wide CRISPR/Cas9 loss-of-function screen investigating the genetic basis of resistance to chemical CDK4/6 inhibition. AMBRA1 loss results in high protein levels of...
ORGANISM(S): Homo sapiens (Human) 
2021-07-24 | PXD021789 | Pride
Human Cancer Cyclin d Cell cycle 
ProteomicsBroad substrate-specific phosphorylation events associated with the initial stage of plant cell wall recognition in Neurospora crassa
Global proteomics and phospho proteomics data from Fungi degrading six different food sources (1 mM D-GalA + 1 mM L-Rha; 2 mM D-Glc; 2 mM D-Xyl; 0.5% cellobiose; 1 mM glucomannodextrins; no carbon) with 4 replicates.
ORGANISM(S): Neurospora crassa 
2020-01-09 | PXD013964 | Pride
Phosphopeptides Proteomics Degradation 
UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
ProteomicsFrom plants to ants: Evaluating lipidomic changes in leaf-cutter ant fungus gardens
Leaf-cutter ants use fresh plant material to cultivate an obligate mutualistic fungus Leucoagaricus gongylophorus in specialized fungus gardens to access and transform nutrients from plant biomass that would otherwise be unavailable to the ants. Here, we evaluated the lipidomic differences between t...
ORGANISM(S): Environmental Samples <bacteria> (ncbitaxon:48479) 
2019-10-30 | MSV000084520 | MassIVE
MetabolomicsDisease progression-associated alterations in fecal metabolites in SAMP1/YitFc mice, a Crohn’s disease model

INTRODUCTION: Crohn’s disease (CD) is a chronic, relapsing inflammatory bowel disease affecting the gastrointestinal tract. Although its precise etiology has not been fully elucidated, imbalance of the intestinal microbiota has been known to play a role in CD. Fecal metabolites m...

2020-02-09 | MTBLS1209 | MetaboLights
UnknownImaging the distribution of sodium dodecyl sulfate in skin by confocal Raman and infrared microspectroscopy.
Not available
S-EPMC3399083 | biostudies-literature
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
UnknownQuantitation of pretreatment serum interferon-γ-inducible protein-10 improves the predictive value of an IL28B gene polymorphism for hepatitis C treatment response.
Not available
S-EPMC3083026 | biostudies-literature
UnknownDeletion of choline acetyltransferase in enteric neurons results in postnatal intestinal dysmotility and dysbiosis.
Not available
S-EPMC6103169 | biostudies-literature
UnknownThrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions.
Not available
S-EPMC2438399 | biostudies-literature
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