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TranscriptomicsTranscription profiling of Drosophila developmental time series
Michelle N. Arbeitman, Eileen E. M. Furlong, Farhad Imam, Eric Johnson, Brian H. Null, Bruce S. Baker, Mark A. Krasnow, Matthew P. Scott, Ronald W. Davis and Kevin P. White. Gene Expression During the Life Cycle of Drosophila melanogaster, Science, 297: 2270-2275, 2002. This work can be accessed fro...
ORGANISM(S): Drosophila melanogaster 
2004-11-06 | E-FLYC-6 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of various types of murine cerebellum cells to investigate the pre-neoplastic stage of medulloblastoma
SUMMARY; Medulloblastoma is the most common malignant brain tumor in children. It is thought to result from transformation of granule cell precursors (GCPs) in the developing cerebellum, but little is known about the early stages of the disease. Here we identify a pre-neoplastic stage of medulloblas...
ORGANISM(S): Mus musculus 
2007-08-31 | E-GEOD-2426 | biostudies-arrayexpress
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
TranscriptomicsGenome-wide binding of Ubx and Hth in 3rd thoracic imaginal discs
The Hox genes are responsible for generating morphological diversity along the anterior-posterior axis during animal development. The Drosophila Hox gene Ultrabithorax (Ubx), for example, is required for specifying the identity of the third thoracic (T3) segment of the adult, which includes the dors...
ORGANISM(S): Drosophila melanogaster 
2011-01-21 | E-GEOD-26793 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Candida albicans populations exposed to a temperature shift from 25 degrees to 37 degrees
Seperate White and Opaque Candida albicans populations were exposed to a temperature shift from 25 degrees to 37 degrees. Samples were then harvested at various time points to follow the effects of the shift on the two cell types, particularly the opaque cell type which switches to the white cell ...
ORGANISM(S): Candida albicans 
2011-05-08 | E-MEXP-2705 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of C. albicans to identify the commintment point of the temperature induced opaque-to-white switch
This experiment is a characterization of the commitment point of the temperature induced opaque-to-white switch in the fungal pathogen Candida albicans. This experiment examines changes in the transcriptome occurring at the 50% commitment points for both the wild type and WOR1/wor1 strains in order...
ORGANISM(S): Candida albicans 
2011-07-07 | E-MEXP-2834 | biostudies-arrayexpress
Genomics4C and Capture-C in HCT116, NCM460 cells and colon tissue
One of the strongest associated type 2 diabetes (T2D) loci reported to date resides within the TCF7L2 gene. Previous studies point to the T allele of rs7903146 in intron 3 as the causal variant at this locus. To aid in the identification of the actual gene(s) under the influence of this variant, we ...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-MTAB-4845 | biostudies-arrayexpress
TranscriptomicsPre-Neoplastic Stage of Medulloblastoma
SUMMARY Medulloblastoma is the most common malignant brain tumor in children. It is thought to result from transformation of granule cell precursors (GCPs) in the developing cerebellum, but little is known about the early stages of the disease. Here we identify a pre-neoplastic stage of medulloblast...
ORGANISM(S): Mus musculus 
2005-03-22 | GSE2426 | GEO
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
TranscriptomicsGenome-wide binding of Sd and Yki in imaginal discs
The transcription cofactor Yki drives growth and proliferation in part by controlling mitochondrial network formation. To determine if Yki and Sd are directly bound to DNA corresponding to mitochondrial genes, we used chromatin immunoprecipitation and whole genome tiling arrays (ChIP-chip) to identi...
ORGANISM(S): Drosophila melanogaster 
2012-10-03 | E-GEOD-26678 | biostudies-arrayexpress
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