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MetabolomicsLongitudinal Deep Multi-Omics Profiling in aCLN3Δex7/8Minipig Model Reveals Novel Biomarker Signatures for Batten Disease
Development of therapies for CLN3 Batten disease, a rare pediatric lysosomal storage disorder, has been hindered by the lack of etiological insights and translatable biomarkers to clinics. Here, we used a deep multi-omics approach to discover new biomarkers using longitudinal serum samples from a po...
2025-08-13 | MTBLS1107 | MetaboLights
UnknownCombination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma.
Not available
S-EPMC4437699 | biostudies-literature
TranscriptomicsMicroarray analysis from paired biopsies from ileal pouch-anal anastomosis surgery patients with ulcerative colitis and familial adenomatous polyposis
Pouchitis is a common complication for ulcerative colitis (UC) patients with ileal pouch-anal anastomosis (IPAA) surgery. Similarly to IBD, both innate host factors such as genetics, and environmental stimuli including the tissue-associated microbiome have been implicated in the pathogenesis. In thi...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-65270 | biostudies-arrayexpress
UnknownImmunogenicity of the Ad26.COV2.S Vaccine for COVID-19.
Not available
S-EPMC7953339 | biostudies-literature
UnknownNipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties.
Not available
S-EPMC11834464 | biostudies-literature
UnknownA new subspecies of Trypanosoma cyclops found in the Australian terrestrial leech Chtonobdella bilineata.
Not available
S-EPMC8311967 | biostudies-literature
UnknownDownregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children.
Not available
S-EPMC8357784 | biostudies-literature
UnknownEleven High-Quality Reference Genome Sequences and 360 Draft Assemblies of Shiga Toxin-Producing Escherichia coli Isolates from Human, Food, Animal, and Environmental Sources in Canada.
Not available
S-EPMC6787312 | biostudies-literature
UnknownIbrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b/2 trial.
Not available
S-EPMC4134524 | biostudies-literature
UnknownMammaPrint predicts chemotherapy benefit in HR+HER2- early breast cancer: FLEX Registry real-world data.
Not available
S-EPMC12413225 | biostudies-literature
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