Downregulation of exhausted cytotoxic T cells in gene expression networks of multisystem inflammatory syndrome in children.

ABSTRACT: Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation and pathology of multiple organs in individuals under 21 years of age in the weeks following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although an autoimmune pathogenesis has been proposed, the genes, pathways and cell types causal to this new disease remain unknown. Here we perform RNA sequencing of blood from patients with MIS-C and controls to find disease-associated genes clustered in a co-expression module annotated to CD56^dimCD57⁺ natural killer (NK) cells and exhausted CD8⁺ T cells. A similar transcriptome signature is replicated in an independent cohort of Kawasaki disease (KD), the related condition after which MIS-C was initially n

SUBMITTER: Beckmann ND 

PROVIDER: S-EPMC8357784 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature