IL27 gene expression distinguishes multisystem inflammatory syndrome in children from febrile illness in a South African cohort.

ABSTRACT:

Introduction

Multisystem inflammatory syndrome in children (MIS-C) is a severe acute inflammatory reaction to SARS-CoV-2 infection in children. There is a lack of data describing differential expression of immune genes in MIS-C compared to healthy children or those with other inflammatory conditions and how expression changes over time. In this study, we investigated expression of immune-related genes in South African MIS-C patients and controls.

Methods

The cohort included 30 pre-treatment MIS-C cases and 54 healthy non-inflammatory paediatric controls. Other controls included 34 patients with juvenile systemic lupus erythematosus, Kawasaki disease or other inflammatory conditions. Longitudinal post-treatment MIS-C specimens were available at various timepoints. Expression

SUBMITTER: Spracklen TF 

PROVIDER: S-EPMC9486543 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature