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TranscriptomicsExpression data from tail skin in young (5 months) and old (30 months) CB6F1 mice
Background: Skin aging is associated with intrinsic processes that compromise structure of the extracellular matrix while promoting loss of functional and regenerative capacity. These processes are accompanied by a large-scale shift in gene expression, but underlying mechanisms are not understood an...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-35322 | biostudies-arrayexpress
TranscriptomicsGene expression in psoriasis lesions and uninvolved skin
Psoriasis is a chronic inflammatory skin disease characterized by marked proliferation of keratinocytes leading to pronounced epidermal hyperplasia, elongation of rete ridges and hyperkeratosis. The most common form of psoriasis, chronic plaque psoriasis (Psoriasis vulgaris), involves relatively sta...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-50790 | biostudies-arrayexpress
UnknownUntargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease.
Not available
S-EPMC4372431 | biostudies-literature
TranscriptomicsSystem-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms
Detailed analysis of disease-affected tissue provides insight into molecular mechanisms contributing to pathogenesis. Substantia nigra, striatum and cortex are functionally connected with increasing degrees of alpha-synuclein pathology in Parkinson's disease. Functional and causal pathway analysis o...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-54282 | biostudies-arrayexpress
TranscriptomicsEarly tissue responses to etanercept in psoriasis lesions
Anti-TNF-alpha therapy has made a significant impact on the treatment of psoriasis. Despite being designed to neutralize TNF-alpha activity, the mechanism of action of these agents in the resolution of psoriasis remains unclear. The aim of this study was to better understand the mechanism of action ...
ORGANISM(S): Homo sapiens 
2014-06-07 | E-GEOD-47751 | biostudies-arrayexpress
UnknownAn octameric PqiC toroid stabilises the outer-membrane interaction of the PqiABC transport system.
Not available
S-EPMC10897342 | biostudies-literature
TranscriptomicsRice perception of symbiotic arbuscular mychorrhizal fungi requires the karrikin receptor complex
In terrestrial ecosystems plants take up phosphate predominantly via association with arbuscular mycorrhizal fungi (AMF). We discovered that the loss of responsiveness to AMF in the rice deletion mutant hebiba is encoded by the alpha/beta fold hydrolase, DWARF 14 LIKE (D14L), which is one of the 26 ...
ORGANISM(S): Oryza sativa Japonica Group 
2016-03-14 | E-MTAB-4072 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of human pancreatic adenocarcinoma cancer tissues
RNA-seq profiling was conducted on clinically-annotated human pancreatic adenocarcinoma cancer tissues We measured the transcriptome in 51 clinically-annotated human pancreatic adenocarcinoma cancer tissues
ORGANISM(S): Homo sapiens 
2016-06-11 | E-GEOD-79668 | biostudies-arrayexpress
UnknownNatural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom.
Not available
S-EPMC8111053 | biostudies-literature
UnknownEffectiveness of mRNA Covid-19 Vaccine among U.S. Health Care Personnel.
Not available
S-EPMC8482809 | biostudies-literature
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