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ProteomicsHIV-1 activates T cell signaling independently of antigen to drive viral spread
HIV-1 spreads between CD4 T cells most efficiently through virus-induced cell-cell contacts. To test whether this process potentiates viral spread by activating signaling pathways we developed an approach to analyze the phosphoproteome in infected and uninfected mixed population T cells using differ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD005658 | Pride
T cell Hiv Phosphorylation Virological synapse 
TranscriptomicsMolecular reprogramming of primary human resting memory CD4+ T cells by HIV-1 Vpr
Resting CD4+ T cells are infected by HIV-1 in vivo, however are refractory to cell-free HIV-1 infection in vitro. We show that they are efficiently infected by cell-to-cell spread. To allow resting T cell infection, uninfected resting target cells were co-cultured with infected donor T cells. Cells ...
ORGANISM(S): Homo sapiens 
2022-03-31 | E-MTAB-11454 | biostudies-arrayexpress
TranscriptomicsRNA-seq time-course of Calu-3 cells infected with SARS-CoV-2 early-lineage and Alpha variant viruses
Emergence of SARS-CoV-2 variants of concern (VOCs), including the globally successful Alpha (B.1.1.7) variant, suggests viral adaptation to enhance human-to-human transmission. Although much effort has focused on characterisation of spike changes, Alpha mutations outside spike likely contribute to a...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-11275 | biostudies-arrayexpress
UnknownImplantable cardioverter defibrillator and cardiac resynchronization therapy use in New Zealand (ANZACS-QI 33).
Not available
S-EPMC7011834 | biostudies-literature
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