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UnknownHoliday waistline. Jolly, fit and fat: should we be singing the "Santa Too Fat Blues"?
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S-EPMC1660598 | biostudies-literature
TranscriptomicsNFATc1 controls the survival, function and suppressive capacity of B lymphocytes upon B cell receptor stimulation
Triggering of B cell receptors (BCR) induces a massive synthesis of NFATc1 in splenic B cells. By inactivating the Nfatc1 gene and re-expressing NFATc1 we show that NFATc1 levels are critical for the survival of splenic B cells upon BCR stimulation. NFATc1 ablation led to decreased BCR-induced Ca++ ...
ORGANISM(S): Mus musculus 
2011-03-23 | E-GEOD-21063 | biostudies-arrayexpress
ProteomicsMicroenvironment Shapes Small Cell Lung Cancer Neuroendocrine States and Presents Unique Therapeutic Opportunities
Small-cell lung cancer (SCLC) is the most fatal form of lung cancer. Intra-tumoral heterogeneity, marked by neuroendocrine (NE) and non-neuroendocrine (non-NE) cell states, defines SCLC, but the drivers of SCLC plasticity are poorly understood. To map the landscape of SCLC tumor microenvironment (TM...
ORGANISM(S): Homo sapiens (Human) 
2024-05-15 | PXD052033 | Pride
Small cell lung cancer  tumor microenvironment  tumor heterogeneity  spatial transcriptomics  cancer associated fibroblasts  intercellular communication  rapid research autopsy 
UnknownPredictive Power Estimation Algorithm (PPEA)--a new algorithm to reduce overfitting for genomic biomarker discovery.
Not available
S-EPMC3174148 | biostudies-literature
UnknownBiomarkers of splenic function in infants with sickle cell anemia: baseline data from the BABY HUG Trial.
Not available
S-EPMC3062353 | biostudies-literature
TranscriptomicsTranscription profiling of rat liver samples treated with clofibrate, valproic acid and diethylhexylphthalate
The project had 2 goals:; 1) To evaluate the transcriptional response of 3 prototypical toxicants (Clofibrate, VPA, and DEHP) on rat lever. 2) To evaluate the impact pooling samples has on data analysis. Experiment Overall Design: Male SD rats were given a single dose of one of 3 prototypical toxica...
ORGANISM(S): Rattus norvegicus 
2007-10-08 | E-GEOD-2303 | biostudies-arrayexpress
no omics definedTranscription profiling of rat liver pooled vs. individual samplesf rom a single-dose time-course rat study in response to the prototypical toxicants Clofibrate [CAS:637-07-0;CHEBI:3750], Diethylhexyl phthalate DEHP [CAS:117-81-7;CHEBI:17243], and valproic acid VPA [CAS:1069-66-5;CHEBI:9925],
Combining or pooling individual samples when carrying out transcript profiling using microarrays is a fairly common means to reduce both the cost and complexity of data analysis. However, pooling does not allow for statistical comparison of changes between samples and can result in a loss of informa...
ORGANISM(S): Rattus norvegicus 
2006-04-10 | E-TOXM-19 | biostudies-arrayexpress
UnknownViperin is an important host restriction factor in control of Zika virus infection.
Not available
S-EPMC5493656 | biostudies-literature
UnknownAlu insertion polymorphisms shared by Papio baboons and Theropithecus gelada reveal an intertwined common ancestry.
Not available
S-EPMC6880559 | biostudies-literature
UnknownMutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly.
Not available
S-EPMC6917859 | biostudies-literature
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