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Ependymal tumors across age groups have been classified solely by histopathology. It is, however, commonly accepted that this classification has limited clinical utility based on its poor reliability. We aimed at establishing a reliable and reproducible molecular classification using DNA methylation...
ORGANISM(S): Homo sapiens 
DATA FILES FOR PCGP MB WGS - Supersedes (EGAD00001000269)
OLD DATA FILES FOR SJMB - Superseded by EGAD00001001864
Medulloblastoma is a heterogenous disease made up of at least four distinct subtypes of disease which appear to exploit and disrupt naturally occurring developmental pathways of cellular growth and hindbrain development. To better understand the driver mutations of this disease, we performed whole g...
release_2: ICGC PedBrain: whole exome sequencing and Target-Seq
release_2: ICGC PedBrain: RNA sequencing
Whole genome bisulfite sequencing of pedbrain - medulloblastoma
4C-seq data was generated for regions of interest to confirm enhancer-gene promoter interactions
Illumina HiSeq sequence data (with >80x coverage) were aligned to the hg19 human reference genome assembly using BWA (Li and Durbin, 2009); duplicate reads were removed from the final BAM file. No realignment or recalibration was performed.
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