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UnknownPractices That Support and Sustain Health in Schools: An Analysis of SHPPS Data.
Not available
S-EPMC11949313 | biostudies-literature
TranscriptomicsStructural, Functional and Molecular Impact on the Cardiovascular System in ApoE-/- Mice Exposed to Aerosol from modified risk tobacco products, the Carbon Heated Tobacco Product 1.2 and the Tobacco Heating System 2.2 compared to Cigarette Smoke effects (miRNA data).
AIM: To investigate the molecular, structural, and functional impact of aerosols from two heat-not-burn-based MRTPs, the Carbon Heated Tobacco Product (CHTP) 1.2 and Tobacco Heating System (THS) 2.2, compared with that of cigarette mainstream smoke (CS) on the cardiovascular system of ApoE-/- mice. ...
ORGANISM(S): Mus musculus 
2021-08-16 | E-MTAB-7981 | biostudies-arrayexpress
TranscriptomicsCombined Chronic Toxicity and Carcinogenicity of Aerosol from a Heated Tobacco Product (microRNA data).
Smoking cessation is the most effective measure for reducing the risk of smoking-related diseases but switching to less harmful products (modified-risk tobacco products) can be an alternative for smokers who would otherwise not quit. In an 18-month chronic carcinogenicity/toxicity study in A/J mice ...
ORGANISM(S): Mus musculus 
2020-08-17 | E-MTAB-8541 | biostudies-arrayexpress
TranscriptomicsA Six-Month Systems Toxicology Inhalation/Cessation Study in ApoE-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of Modified Risk Tobacco Products, CHTP 1.2 and THS 2.2, Compared with Conventional Cigarettes (miRNA data)
Smoking is one of the major modifiable risk factors in the development and progression of chronic obstructive pulmonary disease (COPD) and cardiovascular disease (CVD). Modified-risk tobacco products (MRTP) are being developed to provide substitute products for smokers who are unable or unwilling t...
ORGANISM(S): Mus musculus 
2019-04-18 | E-MTAB-7892 | biostudies-arrayexpress
TranscriptomicsApplication of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using a novel e-cigarette device with MESH(TM) technology (mRNA data)
We previously put forward a multi-layer systems toxicology framework for in vitro assessment of e-liquids that is meant to complement the battery of classical assays for genotoxicity testing. The framework started with the first layer to screen e-liquids for their potential toxicity, followed by the...
ORGANISM(S): Homo sapiens 
2019-11-01 | E-MTAB-7911 | biostudies-arrayexpress
TranscriptomicsApplication of a multi-layer systems toxicology framework for in vitro assessment of the biological effects of Classic Tobacco e-liquid and its corresponding aerosol using a novel e-cigarette device with MESH(TM) technology (microRNA data)
We previously put forward a multi-layer systems toxicology framework for in vitro assessment of e-liquids that is meant to complement the battery of classical assays for genotoxicity testing. The framework started with the first layer to screen e-liquids for their potential toxicity, followed by the...
ORGANISM(S): Homo sapiens 
2019-11-01 | E-MTAB-7912 | biostudies-arrayexpress
UnknownRapid recovery of life at ground zero of the end-Cretaceous mass extinction.
Not available
S-EPMC6058194 | biostudies-literature
UnknownLow-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2.
Not available
S-EPMC5687844 | biostudies-literature
GenomicsEGAD00000000054
NCI-H209 is an immortal cell line derived from a bone marrow metastasis of a patient with small cell lung cancer, taken before chemotherapy. The specimen showed histologically typical small cells with classic neuroendocrine features. NCI-BL209 is an EBV-transformed B-cell line derived from the same ...
EGAD00000000054 | EGA
GenomicsA small cell lung cancer genome reports complex tobacco exposure signatures
Cancer is driven by mutation. Worldwide, tobacco smoking is the major lifestyle exposure that causes cancer, exerting carcinogenicity through 60 chemicals that bind and mutate DNA. Using massively parallel sequencing technology, we sequenced a small cell lung cancer cell line, NCI-H209, to explore t...
EGAS00000000051 | EGA
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