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ProteomicsThe Prostacyclin Receptor is a NRF2-regulated Immune Checkpoint in CD8 T cells
Immune checkpoint inhibitor (ICI) therapies revitalize anti-cancer responses by intercepting protein-protein interactions between exhausted CD8 T (Tex) cells and cancer cells (e.g. PD-1:PD-L1). However, up to 50% of patients receiving ICIs relapse, warranting further interrogation of the underpinnin...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-25 | PXD052688 | Pride
Adoptive cell therapy T cell exhaustion Immune checkpoint 
UnknownAn exploration of the genetic epidemiology of non-suicidal self-harm and suicide attempt.
Not available
S-EPMC8066869 | biostudies-literature
UnknownAutosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH.
Not available
S-EPMC419998 | biostudies-literature
UnknownSecond malignancies in the context of lenalidomide treatment: an analysis of 2732 myeloma patients enrolled to the Myeloma XI trial.
Not available
S-EPMC5223149 | biostudies-literature
UnknownWAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis.
Not available
S-EPMC11803114 | biostudies-literature
UnknownLenalidomide maintenance versus observation for patients with newly diagnosed multiple myeloma (Myeloma XI): a multicentre, open-label, randomised, phase 3 trial.
Not available
S-EPMC6318225 | biostudies-literature
UnknownResponse-adapted intensification with cyclophosphamide, bortezomib, and dexamethasone versus no intensification in patients with newly diagnosed multiple myeloma (Myeloma XI): a multicentre, open-label, randomised, phase 3 trial.
Not available
S-EPMC7043012 | biostudies-literature
UnknownCarfilzomib, lenalidomide, dexamethasone, and cyclophosphamide (KRdc) as induction therapy for transplant-eligible, newly diagnosed multiple myeloma patients (Myeloma XI+): Interim analysis of an open-label randomised controlled trial.
Not available
S-EPMC7799846 | biostudies-literature
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
UnknownThe National Lung Screening Trial: overview and study design.
Not available
S-EPMC3009383 | biostudies-literature
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