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Transcriptomicsdocetaxel response prediction MEEBO
Using gene expression profiling of mammary tumors generated in a mouse model for BRCA1-associated breast cancer we have searched for markers that correlate with response to the anti-cancer drugs docetaxel or cisplatin. To validate the results, the analysis was done on 2 different platforms (39K Mous...
ORGANISM(S): Mus musculus 
2011-10-26 | E-MTAB-415 | biostudies-arrayexpress
Transcriptomicsdocetaxel response predic Illumina
Using gene expression profiling of mammary tumors generated in a mouse model for BRCA1-associated breast cancer we have searched for markers that correlate with response to the anti-cancer drugs docetaxel or cisplatin. To validate the results, the analysis was done on 2 different platforms (39K Mous...
ORGANISM(S): Mus musculus 
2011-10-26 | E-MTAB-413 | biostudies-arrayexpress
TranscriptomicsaCGH analysis of Palb2GT/+;p53-/- and Palb2+/+;p53-/- lymphomas
Palb2 interacts with BRCA1 and BRCA2 in supercomplexes involved in DNA repair via homologous recombination. Heterozygous germline mutations in PALB2 confer a moderate risk of breast cancer while biallelic PALB2 mutations are linked to a severe form of Fanconi anaemia characterized by early childhood...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26723 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse tumours derived from sorted Brca1/p53-deficient cell subpopulations
Gene expression of tumors derived from sorted Brca1/p53-deficient cell subpopulations
ORGANISM(S): Mus musculus 
2010-12-15 | E-NCMF-33 | biostudies-arrayexpress
TranscriptomicsSuppression of BRCA1 sensitizes to proteasome inhibitors in DNA repair-independent manner.
Germline and somatic mutations in BRCA1predispose to breast cancer. We found that proteasome inhibitors can selectively kill BRCA1-depleted cells. The toxic response involves a deregulation of the G1/S cell cycle checkpoint via hyperphosphorylation of RB1, 53BP1-mediated arrest at G2/M checkpoint, ...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-56280 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Brca1- and p53-deficient mouse mammary tumors to treatment with doxorubicin, docetaxel or cisplatin
We have studied in vivo responses of spontaneous Brca1- and p53-deficient mouse mammary tumors to treatment with doxorubicin, docetaxel or cisplatin.
ORGANISM(S): Mus musculus 
2007-06-18 | E-NCMF-5 | biostudies-arrayexpress
MetabolomicsIntegration of metabolomics, genomics and immune phenotypes reveals the causal roles of metabolites in disease

BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.

RESULT: We systematically investigate circulating metabolites in a cohort of 5...

2021-06-14 | MTBLS2633 | MetaboLights
GenomicsICGC breast cancer sequencing project SNP6 data
Affymetrix SNP6.0 breast cancer genome sequencing data
EGAD00010000915 | EGA
GenomicsEGAS00001000195-sc-20150416 - samples
We propose to definitively characterise the somatic genetics of breast cancer through generation of comprehensive catalogues of somatic mutations in breast cancer cases by high coverage genome sequencing coupled with integrated transcriptomic and methylation analyses.
EGAD00001001337 | EGA
GenomicsEGAS00001000042-sc-20150416 - samples
We propose to definitively characterise the somatic genetics of breast cancer through generation of comprehensive catalogues of somatic mutations in breast cancer cases by high coverage genome sequencing coupled with integrated transcriptomic and methylation analyses.
EGAD00001001334 | EGA
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