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TranscriptomicsThe transcriptional program controlled by Runx1 during early hematopoietic development
This SuperSeries is composed of the following subset Series: GSE29112: The transcriptional program controlled by Runx1 during early hematopoietic development (expression data) GSE29514: The transcriptional program controlled by Runx1 during early hematopoietic development (ChIP-seq data) Refer to in...
ORGANISM(S): Mus musculus 
2012-05-30 | E-GEOD-29515 | biostudies-arrayexpress
TranscriptomicsThe transcriptional program controlled by Runx1 during early hematopoietic development (expression data)
Transcription factors have long been recognised as powerful regulators of mammalian development, yet it is largely unknown how individual key regulators operate within wider regulatory networks. Here we have used a combination of global gene expression and chromatin-immunoprecipitation approaches a...
ORGANISM(S): Mus musculus 
2012-05-29 | E-GEOD-29112 | biostudies-arrayexpress
GenomicsGenome-wide analysis of GATA1, GATA2, RUNX1, FLI1 and SCL binding in primary human megakaryocytes
We have mapped the binding sites for the five key regulators GATA1, GATA2, RUNX1, FLI1 and TAL1/SCL in primary human megakaryocytes. Statistical analysis identified subsets of enriched as well as depleted combinatorial binding patterns. In particular simultaneous binding by all 5 factors was highly ...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-24674 | biostudies-arrayexpress
GenomicsThe transcriptional program controlled by Runx1 during early hematopoietic development (ChIP-seq data)
Transcription factors have long been recognised as powerful regulators of mammalian development, yet it is largely unknown how individual key regulators operate within wider regulatory networks. Here we have used a combination of global gene expression and chromatin-immunoprecipitation approaches a...
ORGANISM(S): Mus musculus 
2012-05-30 | E-GEOD-29514 | biostudies-arrayexpress
TranscriptomicsGastric lymph node responses to T. circumcincta infection.
The aim of the current study is to identify genes that show differential expression within the gastric lymph node of parasite resistant and susceptible sheep. For this we exploited parasite-naïve Blackface lambs with diversity in their predicted genetic resistance to T. circumcincta, which were tric...
ORGANISM(S): Ovis aries 
2013-05-30 | E-MTAB-1580 | biostudies-arrayexpress
GenomicsGenome-wide analysis of the binding pattern of the transcriptional co-activator Cbp.
The transcriptional coactivator Cbp is critical for hematopoietic stem cell (HSC) development. However, its role in adult HSC and the mechanistic detail of Cbp control of HSC function remain unknown. Using conditional deletion of Cbp in the adult HSC compartment, we demonstrate an altered balance be...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-25265 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of Cbp deficient LSK cells
The transcriptional coactivator Cbp is critical for hematopoietic stem cell (HSC) development. However, its role in adult HSC and the mechanistic detail of Cbp control of HSC function remains unknown. Using conditional deletion of Cbp in the adult HSC compartment, we demonstrate an altered balance b...
ORGANISM(S): Mus musculus 
2011-12-15 | E-GEOD-25268 | biostudies-arrayexpress
GenomicsHigh-throughput single cell gene expression analysis in primary blood stem and progenitor cells identifies new links between key transcriptional regulators
Cellular decision-making is mediated by a complex interplay of external stimuli with the intracellular environment, in particular transcription factor regulatory networks. Here we have determined the expression of a network of 18 key haematopoietic transcription factors (TFs) in 597 single primary ...
ORGANISM(S): Mus musculus 
2013-04-24 | E-GEOD-42518 | biostudies-arrayexpress
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