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TranscriptomicsS. cerevisiae cells: control vs positive supercoiling accumulation in absence of telomere silencing after 0 and 120 min
Positive DNA helical stress accumulates in vivo by the unbalanced relaxation of positive and negative DNA supercoils in M-NM-^Ttop1, top2ts, pGPD:TopA yeast cells. The resulting overwinding of DNA greatly diminishes overall RNA synthesis. Here we show that whereas most genes reduce their transcript ...
ORGANISM(S): Saccharomyces cerevisiae 
2009-12-01 | E-GEOD-18241 | biostudies-arrayexpress
TranscriptomicsSaccharomyces cerevisiae cells: control vs positive supercoiling accumulation after 0, 30 and 120 min
Positive DNA helical stress accumulates in vivo by the unbalanced relaxation of positive and negative DNA supercoils in Δtop1, top2ts, pGPD:TopA yeast cells. The resulting overwinding of DNA greatly diminishes overall RNA synthesis. Here we show that whereas most genes reduce their transcript level...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-19 | E-GEOD-18240 | biostudies-arrayexpress
TranscriptomicsSaccharomyces cerevisiae cells: effect of Top2 depletion without accumulation of positive superhelical stress
Positive DNA helical stress accumulates in vivo by the unbalanced relaxation of positive and negative DNA supercoils in Δtop1, top2ts, pGPD:TopA yeast cells. The resulting overwinding of DNA greatly diminishes overall RNA synthesis. Here we show that whereas most genes reduce their transcript level...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-18605 | biostudies-arrayexpress
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