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TranscriptomicsGene expression comparison of wild-type and IL15ko thymic NKT cells
Semi-invariant natural killer T (NKT) cells are thymus-derived innate lymphocytes that modulate microbial and tumour immunity as well as autoimmune diseases. These immunoregulatory properties of NKT cells are acquired during their development. Much has been learnt regarding the molecular and cell...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-32568 | biostudies-arrayexpress
TranscriptomicsThe Toxoplasma unfolded protein response
To characterize the nature of the unfolded protein response in this Toxoplasma, we carried out microarray analyses to measure the changes in the transcriptome and in translational control during ER stress. Total RNA or RNA fractionated into monosomes or polysomes were purified from parasites treated...
ORGANISM(S): Toxoplasma gondii 
2013-05-24 | E-GEOD-43722 | biostudies-arrayexpress
TranscriptomicsAnalysis of differences in gene expression due to small adaptive mutations in RNA polymerase B' subunit (rpoC)
Studies of the RNA polymerase-binding molecule ppGpp in bacteria and plants have shown that changes to the kinetics of the RNA polymerase can have dramatic biological effects in the short-term as a stress response. Here we describe the reprogramming of the kinetic parameters of the RNAP through mut...
ORGANISM(S): Escherichia coli 
2010-04-12 | E-GEOD-15500 | biostudies-arrayexpress
TranscriptomicsRegulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut
Alterations in the gastrointestinal microbiota have been implicated in obesity in mice and humans, but the conserved microbial functions that influence host energy metabolism and adiposity have not been determined. Here we show that bacterial bile salt hydrolase (BSH) controls a microbe-host dialogu...
ORGANISM(S): Mus musculus 
2014-05-09 | E-GEOD-46952 | biostudies-arrayexpress
UnknownStARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival.
Not available
S-EPMC10203878 | biostudies-literature
no omics definedGenotyping of twenty Pseudomonas aeruginosa strains
20 P. aeruginosa strains were genotyped using a custom spotted oligo array (Ausubel P. aruginosa genotyping 4.8K v1), which included primarily oligos for genes present in strain PA14 but absent in PAO1, and oligos for genes present in PAO1 but absent in PA14 (as well as controls).
ORGANISM(S): Pseudomonas aeruginosa 
2006-10-06 | E-MEXP-824 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat hippocampus from young and aged rats with age-related spatial learning impairments
The aim of this study was to investigate whether the differences in memory decline associated with aging are a result of differences in gene expression. We first categorized age-unimpaired and age-impaired rats based on their performance in the Morris Water Maze and then isolated messenger RNA from...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-3531 | biostudies-arrayexpress
TranscriptomicsCSF-1R inhibition alters macrophage polarization and blocks gliomagenesis
Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor in adults, can be divided into several molecular subtypes including proneural GBM. Most clinical strategies aimed at directly targeting glioma cells in these tumors have failed. A promising alternative is to target str...
ORGANISM(S): Mus musculus 
2013-09-20 | E-GEOD-37475 | biostudies-arrayexpress
TranscriptomicsCancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells (methylation data)
he ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to such reprogramming that must be understood and may provide a model for understanding key events in tum...
ORGANISM(S): Homo sapiens 
2011-06-16 | E-GEOD-29872 | biostudies-arrayexpress
TranscriptomicsCancer-related epigenome changes associated with reprogramming to induced pluripotent stem cells (expression data)
The ability to induce pluripotent stem cells from committed, somatic human cells provides tremendous potential for regenerative medicine. However, there is a defined neoplastic potential inherent to such reprogramming that must be understood and may provide a model for understanding key events in tu...
ORGANISM(S): Homo sapiens 
2011-06-16 | E-GEOD-29870 | biostudies-arrayexpress
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