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TranscriptomicsLNCaP prostate cancer cell lines overexpressing wild-type or GARRPR-mutant Bag-1L
The BF-3 pocket of the androgen receptor (AR) has been identified as an allosteric modulator of the transactivation function of the AR. We now demonstrate that a duplicated GARRPR motif at the N-terminus of the cochaperone Bag-1L functions through this BF-3 domain. Amino acid exchanges in these two ...
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-51524 | biostudies-arrayexpress
UnknownSafety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study.
Not available
S-EPMC5493052 | biostudies-literature
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
TranscriptomicsStudies of target genes for signal transduction pathways (using a Ras1-, a Cdc42- and a Gap1-mutant) in the basidiomycete Schizophyllum commune.
Transcriptome changes associated with signal transduction mutants were analysed in order to identify targets of the distinct pathways of Ras1, Cdc42 and Gap1. Two monokaryons (12-43 and 4-39), a dikaryon (W22 x 12-43), a constitutive active Ras1 mutant (T2G12V, monokaryon), a Cdc42 mutant (G12V, mon...
ORGANISM(S): Schizophyllum commune 
2013-02-01 | E-GEOD-43965 | biostudies-arrayexpress
UnknownHigh-throughput 3D engineered paediatric tumour models for precision medicine
Not available
S-BIAD2130 | bioimages
UnknownExtracorporeal Life Support Organization Registry International Report 2022: 100,000 Survivors.
Not available
S-EPMC10962646 | biostudies-literature
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