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TranscriptomicsIdentification of metastamirs as metastasis-associated microRNAs in clear cell renal cell carcinomas
Background/Objective: MicroRNAs (miRNAs) play a pivotal role in cancerogenesis and cancer progression, but their specific role in metastasis of clear cell renal cell carcinomas (ccRCCs) as so-called metastamirs is still limited. Based on microRNA microarray analyses from normal (n=12) and cancerous ...
ORGANISM(S): Homo sapiens 
2013-02-26 | E-GEOD-37989 | biostudies-arrayexpress
TranscriptomicsExpression data from in vitro derived dendritic cells generated in the presence of FLT3-L from wt and miR-142-/- BM cells
2 types of dendritic cells (DCs) can be generated in vitro in the presence of Flt3-L: CD4+ equivalent CD24- DCs and CD8+ equivalent CD24+ DCs. miR-142-/- mice show a severe defect in the generation of CD4+ equivalent CD24- DCs. To understand the underlying mechanism, RNA expression was analyzed by A...
ORGANISM(S): Mus musculus 
2012-11-16 | E-GEOD-42325 | biostudies-arrayexpress
TranscriptomicsTranscription profile of CD103- vs CD103+ dendritic cells derived from CX3CR1+c-kit+- bone marrow cells (M1993 M2067)
We hypothesize that under homeostatic as well as inflammatory conditions circulating monocytes and/or their bone marrow-derived progenitors might contribute to the replenishment of CD103+ and CD103- DC in lymphoid and non-lymphoid compartments. To that end, bone marrow cells from CX3CR1+/gfp C57BL/6...
ORGANISM(S): Mus musculus 
2008-12-17 | E-GEOD-10882 | biostudies-arrayexpress
TranscriptomicsMacrophage-restricted Interleukin-10 receptor-, but not IL-10 deficiency causes severe spontaneous colitis
Interleukin-10 (IL-10) is a pleiotropic anti-inflammatory cytokine produced and sensed by most hematopoietic cells. Genome wide association studies and experimental animal models point at a central role of the IL-10 axis in Inflammatory Bowel Diseases. Here we investigated the importance of intestin...
ORGANISM(S): Mus musculus 
2014-05-09 | E-GEOD-56444 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of mouse splenic Dendritic cells subsets
We describe a novel subset of CD8+ DCs in lymphoid organs of naïve mice characterized by expression of the CX3CR1 chemokine receptor. CX3CR1+CD8+ DCs lack hallmarks of classical CD8+ DCs, including IL12 secretion, the capacity to cross-present antigen and their developmental independence of the tran...
ORGANISM(S): Mus musculus 
2010-07-28 | E-GEOD-23212 | biostudies-arrayexpress
TranscriptomicsscRNA-seq study of hippocampal microglia, perivascular macrophages and perivascular fibroblasts in pre-plaque APP-KI mice
Aim of this experiment was to characterize whether SPP1 released from the hippocampal perivascular space could imprint microglia transcriptional states. We performed scRNA-seq analysis on sorted CD140a+ perivascular fibroblast (PVF), CD45highCD11intCD206+ perivascular macrophage (PVM) and CD45intCD1...
ORGANISM(S): Mus musculus 
2024-02-09 | E-MTAB-11918 | biostudies-arrayexpress
TranscriptomicsCell-type specific phenotypic characterization of Lyve1+ perivascular macrophages and Sall1+ microglia pooled from PBS and amyloid-β-injected mice
RiboTag-based translatome analysis of pooled oAβ and PBS-challenged brain homogenates of Cx3cr1ccre:Lyve1ncre (n=8 mice) and Cx3cr1ccreSall1ncre:RiboTag-mice (n=4 mice).
ORGANISM(S): Mus musculus 
2023-01-10 | E-MTAB-12515 | biostudies-arrayexpress
UnknownCytogenetic prognostication within medulloblastoma subgroups.
Not available
S-EPMC3948094 | biostudies-literature
TranscriptomicsIntestinal ablation of CKIalpha highlights invasiveness control
Wnt signaling, which drives the rapid self-renewal of the gut epithelium is causally associated with intestinal neoplasia. Here we show that CKIalpha is a activation depends on p53 and p21Waf1/Cip1: CKIα ablation provokes activation of p53 and p21, which assume a pivotal role in suppressing invasiv...
ORGANISM(S): Mus musculus 
2010-10-23 | E-GEOD-24760 | biostudies-arrayexpress
UnknownStandardization of Imaging Criteria for Detecting Macular Fibrosis in Neovascular Age-Related Macular Degeneration.
Not available
S-EPMC12830330 | biostudies-literature
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