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TranscriptomicsValidation of a histology-independent prognostic gene signature for early stage, non-small cell lung cancer including stage IA patients
Background: Patients with early stage non-small cell lung carcinoma (NSCLC) may benefit from treatments based on more accurate prognosis. A 15-gene prognostic classifier for NSCLC was identified from mRNA expression profiling of tumor samples from the NCIC CTG JBR.10 trial. Here, we assessed its val...
ORGANISM(S): Homo sapiens 
2013-12-22 | E-GEOD-50081 | biostudies-arrayexpress
UnknownMicroRNA-34a-5p Promotes Joint Destruction During Osteoarthritis.
Not available
S-EPMC7986901 | biostudies-literature
TranscriptomicsCharacterization of technical variation in ChIP-on-chip studies
Analysis of technical variance of ChIP-on-Chip studies by characterization of Myc-binding in HL60 cells. Keywords: Chip-on-chip Fully-blocked study of technical variance in Myc-binding in HL60 cells. Two different antibodies were used to generate 6 biologically independent replicates each. Each repl...
ORGANISM(S): Homo sapiens 
2008-10-31 | E-GEOD-8448 | biostudies-arrayexpress
Transcriptomicsc-Myc binding in HL60 cells
Analysis of technical variance of ChIP-on-Chip studies by characterization of Myc-binding in HL60 cells. Keywords: Chip-on-chip Characterization of c-Myc binding in HL60 cells. Thirteen biologically independent replicates of growing HL60 cells were subjected to ChIP with an N-terminal c-Myc antibod...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-8447 | biostudies-arrayexpress
TranscriptomicsComparison of genomic DNA amplification methods
Hybridization of amplified genomic DNA against unamplified genomic DNA using three different amplification methods to assess the bias introduced by amplification alone. Keywords: genomic DNA Three different amplification methods were assessed and total genomic DNA hybridized against equal amounts of...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-8449 | biostudies-arrayexpress
TranscriptomicsGenomic markers for malignant progression in pulmonary adenocarcinoma.
Bronchioloalveolar carcinoma (BAC), a subtype of lung adenocarcinoma (ADC) without stromal, vascular, or pleural invasion, is considered an in situ tumor with a 100% survival rate. However, the histological criteria for invasion remain controversial. BAC-like areas may accompany otherwise invasive a...
ORGANISM(S): Homo sapiens 
2008-07-01 | E-GEOD-11945 | biostudies-arrayexpress
Proteomics,MultiomicsPSE115_PSM1063_mouse
Placentas from naturally-mated crosses of C57Bl/6J mice on embryonic day 17.5 were cut into thick slices. A scalpel blade was used to isolate the blood-red labyrin th tissue from the more poorly vascularized, and hence paler, spongiotrophoblast tissue, and to remove the superficial chorionic vascula...
ORGANISM(S): Mus Musculus 
2009-12-31 | PAe001560 | PeptideAtlas
TranscriptomicsMolecular Characterization of 126 Intermediate Risk Prostate Cancer Patient Samples
The primary objective of this study was to correlate genetic alterations from Hh pathway genes with biochemical free relapse rate. aCGH data of 126 intermediate risk men with histologically confirmed adenocarcinoma of the prostate who had chosen radical radiotherapy as their primary treatment betwee...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-41120 | biostudies-arrayexpress
ProteomicsA Global Analysis of Receptor Tyrosine Kinase – Protein Phosphatase Interactome
Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. However, a comprehensive picture of how RTKs functionally associate with phosphatases remains elusive. We aimed to study this problem by using two protein-protein interactio...
ORGANISM(S): Homo sapiens (Human) 
2017-01-11 | PXD004248 | Pride
Tyrosine kinaase Phosphatase interactome 
TranscriptomicsDetermining lovastatin-induced differences in expression between statin sensitive and insensitive MM cells
The goals of this study were to determine global differences in transcript expression and regulation between MM cells that are sensitive or insensitive to lovastatin-induced apoptosis. To this end, two sensitive (KMS11 and H929) and two insensitive (LP1 and SKMM1) MM cell lines treated with 20uM lo...
ORGANISM(S): Homo sapiens 
2010-05-20 | E-GEOD-15946 | biostudies-arrayexpress
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