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TranscriptomicsMicroarray dataset of Jurkat cells following miR-93 over-expression
miR-93 is often dysregulated in several tumor cell lines, including lymphoblastic leukemias. This dataset can represent a further insight into gene expression changes and GO Terms associated with miR-93 over-expression. miR-93 was over-expressed in Jurkat cells by transduction with a lentiviral tran...
ORGANISM(S): Homo sapiens 
2016-03-21 | E-MTAB-4588 | biostudies-arrayexpress
TranscriptomicsIdentification of miR-21 targets in Jurkat cells by AGO2 immunoprecipitation
In order to identify miR-21 targets by a biochemical high-throughput method, we immunopurified RISC Complex and associated mRNAs in both control and miR-21 overexpressing Jurkat cells. Following transduction of miR-21 encoding construct (or a cognate control vector) in Jurkat cells, we used microarr...
ORGANISM(S): Homo sapiens 
2014-10-15 | E-GEOD-37212 | biostudies-arrayexpress
MetabolomicsMetabolomics identifies the intersection of phosphoethanolamine with menaquinone- triggered apoptosis in an in vitro model of leukemia
Altered metabolism is increasingly acknowledged as an important aspect of cancer, and thus serves as a potentially fertile area for the identification of therapeutic targets or leads. Our recent work using transcriptional data to predict metabolite levels in cancer cells led to preliminary evidence ...
2015-10-19 | MTBLS226 | MetaboLights
ProteomicsKinome analysis of CD151 overexpressing Jurkat T cells
The effect of CD151 expression onto the kinome of Jurkat T cells was assessed using kinome analysis. CD151 was expressed in Jurkat T cells by retroviral transduction based on a pMSCV vector. Entrez Gene: 977 UniProtKB: P48509 Jurkat T cells were transduced with the MSCV-CD151 vector and successfull...
ORGANISM(S): Homo sapiens 
2017-09-30 | E-MTAB-5978 | biostudies-arrayexpress
TranscriptomicsExpression data from human Jurkat T cells exposed to 31 compounds
Compounds with direct immunotoxic properties, including metals, mycotoxins, agricultural pesticides and industrial chemicals, form potential human health risks due to exposure through food, drinking water, and the environment. Insights into the mechanisms of action are currently lacking for the majo...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-46909 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human PMA-activated Jurkat cells
Cyclin T1-dependent genes in activated Jurkat cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II el...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10232 | biostudies-arrayexpress
Transcriptomicsrole of miR-146a on Jurkat T cells
screenning the differentially expressed genes of Jurkat-FF3, Jurkat-miR146a, Jurkat-miR146a-sponge cell lines. To investigate the role of miR-146a on Jurkat T cells, we screened the differentially expressed genes of Jurkat-FF3 (as control), Jurkat-miR146a (as miR-146a overexpression cell line), Jur...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-21132 | biostudies-arrayexpress
TranscriptomicsGenome-wide binding map of the HIV Tat protein to the human genome (gene expression)
The HIV-1 Trans-Activator of Transcription (Tat) protein binds to multiple host cellular factors and greatly enhances the level of transcription of the HIV genome. Here, we report the genome-wide binding map of Tat to the human genome in Jurkat T cells (Jurkat-Tat cells) using chromatin immunopreci...
ORGANISM(S): Homo sapiens 
2011-11-06 | E-GEOD-30734 | biostudies-arrayexpress
TranscriptomicsAffymetrix whole transcriptome gene expression analysis of ER-stressed Jurkat cells
We induced ER stress in Jurkat T-cells with dithiothreitol (DTT), which reduces the protein disulfide bonds and causes the accumulation of misfolded proteins in the ER lumen. For assessment of DTT effects on cells, we performed Affymetrix whole transcriptome gene expression analysis. The cells were ...
ORGANISM(S): Homo sapiens 
2017-04-15 | E-MTAB-5574 | biostudies-arrayexpress
MetabolomicsLipidomic characterization of Jurkat-derived T cell line in which the chaperonin complex CCT has been partially silenced
Not available
ORGANISM(S): Homo sapiens 
ST002185 | MetabolomicsWorkbench
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