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TranscriptomicsCharacterization of the granulosa cell tumor transcriptome using RNA-seq
Granulosa cell tumors (GCTs) are rare types of ovarian cancer, consisting of an adult and a juvenile subtype. There has been a lack of research into this specific cancer, especially regarding the differences between the two subtypes. Here we compared the transcriptome of normal ovary (n=1) and GCT (...
ORGANISM(S): Homo sapiens 
2026-05-28 | E-MTAB-14294 | biostudies-arrayexpress
TranscriptomicsOvarian granulosa cell tumor and normal granulosa cells transcriptomes
RNA was extracted from normal human granulosa cells from IVF patients (hGC1 and hGC2 samples) and from adult-type ovarian granulosa cell tumor samples (H1, H8, H20, H23, H24, H28, H30, H33, H4, H18) as described in Jamieson et al, 2010. RNA from all samples was linearly amplified using the Whole Tra...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-MTAB-483 | biostudies-arrayexpress
ProteomicsUnveiling the impact of AKT1 pathogenic variants in Juvenile Granulosa Cell Tumors Using a Drosophila model
Juvenile-type granulosa cell tumors (JGCTs) manifest during the prepubertal period as precocious pseudo-puberty and/or dysmenorrhea. We have previously identified pathogenic variants in AKT1 in JGCTs. The current study aims to understand how these variants affect cellular function at the phenotypic ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-01-12 | PXD060549 | Pride
Fly Juvenile granulosa cell tumors Akt1 Ovary 
GenomicsMutation of FOXL2 in granulosa cell tumors of the ovary
We generated paired-end RNA-Seq data using the Illumina Genome Analyzer II platform for four adult granulosa cell tumours (GCTs) of the ovary (1 primary, 3 recurrent). We screened this data for the presence of GCT specific sequence variants and detected a non-synonymous mutation in the FOXL2 gene th...
EGAS00000000040 | EGA
ProteomicsAkt1 depletion in murine ovarian granulosa cells reveals known and novel molecular and cellular processes dependent on this kinase
The PI3K/AKT signaling pathway is known to regulate a broad range of cellular processes and it is often altered in several types of cancers. Recently, somatic AKT1 mutations leading to a strong activation of this kinase have been reported in juvenile granulosa cell tumors. However, the molecular rol...
ORGANISM(S): Mus musculus (Mouse) 
2019-04-30 | PXD012548 | Pride
Proteomics Knock-down Akt1 Mouse Transcriptomics Granulosa cells 
UnknownOvarian juvenile granulosa cell tumors with Ollier's disease in children with IDH1 gene somatic mutation.
Not available
S-EPMC10265673 | biostudies-literature
GenomicsIntegrated analysis of ovarian juvenile granulosa cell tumors reveals distinct epigenetic signatures and recurrent TERT rearrangements
Integrated analysis of ovarian juvenile granulosa cell tumors reveals distinct epigenetic signatures and recurrent TERT rearrangements
PRJNA793908 | ENA
UnknownSmad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors.
Not available
S-EPMC2819741 | biostudies-literature
UnknownBiallelic MAD2L1BP (p31comet) mutation is associated with mosaic aneuploidy and juvenile granulosa cell tumors.
Not available
S-EPMC10721328 | biostudies-literature
GenomicsEGAD00000000047
Signal data for from 3 recurrent and 1 ovarian primary Granulosa Cell Tumour samples
EGAD00000000047 | EGA
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