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MetabolomicsDisruption of Methionine Metabolism Drives Erythroid Cell Fate Reprogramming by Remodeling the H3K4me3 Landscape

Methionine cycle plays critical roles in cell fate determination by shaping epigenetic landscape, yet its function in human erythropoiesis remains undefined. Here, we show that disruption of methionine metabolism by compromising key enzyme adenosylhomocysteinase (AHCY) reshapes H3K4me3 landscape,...

2026-06-10 | MTBLS10469 | MetaboLights
MetabolomicsTCA cycle metabolomics of H3K27M Cell Nucleus Fraction and Cell Mitonchonrdial Fraction (Part-IV)
Not available
ORGANISM(S): Homo sapiens 
ST001026 | MetabolomicsWorkbench
MetabolomicsH3K27M cells and glutamine metabolomics 1 million cell test (part-I)
Not available
ORGANISM(S): Homo sapiens 
ST001023 | MetabolomicsWorkbench
TranscriptomicsA gene expression signature associated with K-Ras addiction reveals regulators of EMT and tumor cell survival
K-Ras mutations occur frequently in epithelial cancers. Using shRNAs to deplete K-Ras in lung and pancreatic cancer cell lines harboring K-Ras mutations, two classes were identified—lines that do or do not require K-Ras to maintain viability. Comparing these two classes of cancer cells revealed a g...
ORGANISM(S): Homo sapiens 
2009-03-06 | E-GEOD-15126 | biostudies-arrayexpress
GenomicsK-562 cell lines
K-562 cell lines
PRJNA1019807 | ENA
TranscriptomicsTranscription profiling of human pancreatic duct epithelial cell line (H6c7) Gene expression changes induced by K-ras oncogene in the
k-ras oncogene was transduced into the HPV16-E6E7 immortalized normal human pancreatic duct epithelial cell line (H6c7) to generate a stable K-ras oncogene-expressing cell line (H6c7-Kr). The gene expression profile of the H6c7-Kr cells was compared to that of H6c7 cells. We have excluded (subtracte...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1955 | biostudies-arrayexpress
ProteomicsIdentification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis
Background: Acute respiratory distress syndrome (ARDS) is characterized by refractory hypoxemia caused by accumulation of pulmonary fluid, which is related to inflammatory cell infiltration, impaired tight junction of pulmonary epithelium and impaired Na, K-ATPase function, especially Na, K-ATPase α...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD032209 | Pride
Lipopolysaccharide A549 cell. Proteomics Na K-atpase α1 Ards 
ProteomicsTEAD inhibitor K-975 enhances KRASG12C inhibitor adagrasib-mediated cancer cell proliferation inhibition via dual cell cycle arrest
Here we investigate the effect of the dual inhibition, in KRASG12C mutated NSCLC cells, using the KRASG12Ci adagrasib (MRTX849) and the pan-TEAD inhibitor (TEADi) K-975. We show that K-975 enhances adagrasib-induced tumor cell growth inhibition in cancer cells. Mechanistically, we detect a downregul...
ORGANISM(S): Homo Sapiens (human) 
2023-05-12 | PXD039726 | JPOST Repository
TranscriptomicsNutrient-dependent growth of NIH3T3 and NIH3T3 K-ras cell lines.
Expression profiling of normal NIH3T3 and transformed NIH3T3 K-ras cell lines grown for 72 hours in optimal glucose availability (25 mM glucose) or low glucose availability (1 mM). Low glucose induces apoptosis in transformed cells as compared to normal ones. We performed genome-wide analysis by usi...
ORGANISM(S): Mus musculus 
2011-07-13 | E-GEOD-29962 | biostudies-arrayexpress
GenomicsT cell homeostasis and antitumor function require the Na+-K+-ATPase
T cell homeostasis and antitumor function require the Na+-K+-ATPase
PRJNA1013809 | ENA
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