K562 cell line - OmicsDI

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GlycoProteomics Laboratory, Department of Parasitology, Institute of Biomedical Sciences, University of Sao Paulo, Avenida Lineu Prestes 1374, CEP 05508-000, Sao Paulo, Brazil (3)
Cellzome (2)
Head of System Biology Lab. at Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency (2)
School of Basic Medical Science, Peking University, China (2)
1.Department of Molecular Biology and Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA, 2.Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA, 3.Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. (1)
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Cellular & Molecular Medicine, University of Bristol, United Kingdom (1)
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Chair of Proteomics and Bioanalytics, Technische Universität München, Germany (1)
Charité - Universitätsmedizin Berlin Research group Biochemistry and Systems Biology of the Metabolism Institute of Biochemistry Germany (1)
Committee on Cancer Biology, The University of Chicago, Chicago, IL, USA Department of Pathology, The University of Chicago, Chicago, IL, USA Department of Pediatrics, The University of Chicago, Chicago, IL, USA The University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA (1)
Department of Biochemistry, Western University (1)
Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte, USA. (1)
Department of Chemistry Chemical Biology Institute (West Campus) Yale University (1)
Department of Chemistry, University of Wisconsin, Madison, WI, United States (1)
Department of Dermatology, Stanford University (1)
Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland Department for BioMedical Research (DBMR), University of Bern, Switzerland (1)
Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China (1)
Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Research Institute for Medical Innovation, Nijmegen, The Netherlands. (1)
Department of Pathology, School of Medicine, Saint Louis University, United States, St. Louis VA Medical Center(VHA), United States (1)
Department of Pediatric Hematology and Oncology, National Center for Tumor Diseases (NCT/UCC) Dresden (1)
Department of oncology UNIL CHUV Ludwig Institute for Cancer Research Lausanne Office B25A/04/94 Rue du Bugnon 25a, CH-1005 Lausanne (1)
Dept of Biopathology and Medical Biotechnologies, section of Biology and Genetics - University of Palermo Via Divisi 83, 90133 Palermo (1)
Dept. Proteomics and Signal Transduction Director at the Max-Planck Institute of Biochemistry (1)
Dpt. of Immunobiology University of Lausanne (UNIL), Boveresses 155 CH-1066 Epalinges (1)
El Bachir Affar, PhD, Professor Department of Medicine, University of Montreal Director of the Cell Signaling and Cancer Research Unit Research Center, Maisonneuve-Rosemont Hospital 5415 Assomption Blvd., Montreal, Quebec, H1T 2M4, CANADA Tel: 514 252-3400 (Ext: 3343) (1)
Faculty of Life Sciences (1)
Faculty of Life Sciences The University of Manchester Manchester, UK (1)
Head Proteomics Group | Leiden University Medical Center |Center for Proteomics and Metabolomics | PO Box 9600 | 2300 RC Leiden | The Netherlands (1)

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Transcriptomes of K562 cell line

To investigate the expression level of genes in K562 cells Profiling the transcriptome of K562

ORGANISM(S): Homo sapiens

2013-07-15 | E-GEOD-39374 | biostudies-arrayexpress

Regulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners

Regulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners Examination of RUNX1 binding in K562 cells, before and following TPA induction and CMK cells. Examination of GATA1 and FOS binding and H3K4me1 and H3K27me3 mo...

ORGANISM(S): Homo sapiens

2011-01-10 | E-GEOD-24777 | biostudies-arrayexpress

Dynamic combinatorial interactions of RUNX1 and cooperating partners regulates megakaryocytic differentiation in cell line models

This SuperSeries is composed of the following subset Series: GSE24777: Regulation of Megakaryocytic differentiation in Cell Line Models by Dynamic Combinatorial Interactions of RUNX1 with Its Cooperating Partners GSE24778: Expresssion data in K562 cells, before and after TPA induction and including ...

ORGANISM(S): Homo sapiens

2011-01-10 | E-GEOD-24779 | biostudies-arrayexpress

Transcription profiling of the human K562 cell line treated with the polyamide-Chl conjugate 1R-Chl

To determine whether the polyamide-Chl conjugate 1R-Chl would cause similar changes in global gene expression in K562 cells, affymetrix gene chip analysis was performed using 1R-Chl. Through class comparison analysis, 1R-Chl affected the levels of transcription and genes of interest were determined...

ORGANISM(S): Homo sapiens

2008-06-16 | E-GEOD-8832 | biostudies-arrayexpress

Dynamics of intercellular and extracellular (exosomal) miRNAs in hypoxic K562 cells

Recently, the existence of extracellular miRNAs enclosed in exosomes has raised the possibility that they play an important role in cell-cell communication. To gain more insight into cell-cell communication via exosomal miRNAs, we investigated whether or not tumor cells exposed to hypoxia secrete ex...

ORGANISM(S): Homo sapiens

2013-12-03 | E-GEOD-45289 | biostudies-arrayexpress

Global analysis of in vivo EGR1-binding sites in erythroleukemia cell K562 using chromatin immunoprecipitation and massively parallel sequencing

Early growth response gene 1 (EGR1) has been implicated in megakaryocyte differentiation induced by PMA (phorbol 12-myristate 13-acetate). The identification of direct EGR1 target genes in global scale is critical for our understanding of how EGR1 contributes to this process. In this study, we provi...

ORGANISM(S): Homo sapiens

2010-09-08 | E-GEOD-21665 | biostudies-arrayexpress

Transcription profiling timecourse of human K562 cell line exposure to hemin

K562 cells (duplicate cultures A & B) are treated with 50 micromolar hemin for 0, 6, 12, 24, 48, 72 hours followed by RNA extraction and gene expression profiling on Affymetrix human U133A arrays and analysis by MAS 5.0

ORGANISM(S): Homo sapiens

2007-07-19 | E-GEOD-1036 | biostudies-arrayexpress

Transcription profiling of human tamoxifen treated myeloid leukemia K562-MERT cells

K562 cells, a myeloid leukemia cells line, were engineered to express a tamoxifen inducible dominant negative Myb (MERT). K562-MERT cells were cultured for 3 days in the absence and presence of 1 uM tamoxifen. The RNA was then extracted from the untreated and tamoxifen treated K562-MERT cells and ...

ORGANISM(S): Homo sapiens

2004-06-30 | E-MEXP-91 | biostudies-arrayexpress

RNA-seq of engineered K562 cell line by CRISPR/Cas9 generation of t(7;12)(q36;p13) chromosomal translocation

We recreated the t(7;12) translocation in K562 cells by CRISPR/Cas9 to understand its effects on haematopoietic cells, which is of relevance to understand how this cytogenetic abnormalities causes and promotes acute leukaemia in infants. Wild-type K562 were edited by electroporation of ribonucleopro...

ORGANISM(S): Homo sapiens

2022-09-06 | E-MTAB-11851 | biostudies-arrayexpress

Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance

Multidrug resistance (MDR) frequently develops in cancer patients exposed to chemotherapeutic agents and is usually brought about by over-expression of P-glycoprotein (P-gp) which acts as a drug efflux pump. MiRNAome profiling using next-generation sequencing identified differentially expressed micr...

ORGANISM(S): Homo sapiens

2013-10-29 | E-GEOD-51774 | biostudies-arrayexpress

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