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TranscriptomicseQTL Analysis Identifies Novel Associations Between Genotype and Gene Expression in the Human Intestine (Illumina SNP)
Genome-wide association studies (GWAS) have been pivotal to increasing our understanding of intestinal disease. However, the mode by which genetic variation results in phenotypic change remains largely unknown, with many associated polymorphisms likely to modulate gene expression. Analyses of expres...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-41238 | biostudies-arrayexpress
TranscriptomicsGene expression changes associated with resistance to intravenous corticosteroid therapy in children with severe ulcerative colitis
Although corticosteroids remain a mainstay of therapy for UC, a meta-regression of cohort studies in acute severe ulcerative colitis (UC) showed that 29% of patients fail corticosteroid therapy and require escalation of medical management or colectomy. We aimed to determine whether genes expressed i...
ORGANISM(S): Homo sapiens 
2010-08-31 | E-GEOD-21231 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis from paired biopsies from ileal pouch-anal anastomosis surgery patients with ulcerative colitis and familial adenomatous polyposis
Pouchitis is a common complication for ulcerative colitis (UC) patients with ileal pouch-anal anastomosis (IPAA) surgery. Similarly to IBD, both innate host factors such as genetics, and environmental stimuli including the tissue-associated microbiome have been implicated in the pathogenesis. In thi...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-65270 | biostudies-arrayexpress
TranscriptomicseQTL Analysis Identifies Novel Associations Between Genotype and Gene Expression in the Human Intestine (Expression)
Genome-wide association studies (GWAS) have been pivotal to increasing our understanding of intestinal disease. However, the mode by which genetic variation results in phenotypic change remains largely unknown, with many associated polymorphisms likely to modulate gene expression. Analyses of expres...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-40292 | biostudies-arrayexpress
TranscriptomicseQTL Analysis Identifies Novel Associations Between Genotype and Gene Expression in the Human Intestine
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-41269 | biostudies-arrayexpress
GenomicsCharacterization of the Gut-Associated Microbiome in Inflammatory Pouch Complications Following Ileal Pouch-Anal Anastomosis

This study involved evaluation of the tissue associated microbiome of the ileal pouch following surgery for ulcerative colitis (UC) or familial adenomatous polyposis (FAP). Individuals were recruited, with biopsies taken from the ileal pouch and the pre-pouch ileum, microbial DNA was extracted an...

phs000659.v1.p1 | EGA
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