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TranscriptomicsEvolutionary analysis across mammals reveals distinct classes of long noncoding RNAs
Recent advances in transcriptome sequencing have enabled the discovery of thousands of long non-coding RNAs (lncRNAs) across many species. Though several lncRNAs have been shown to play important roles in diverse biological processes, the functions and mechanisms of most lncRNAs remain unknown. Two ...
ORGANISM(S): Homo sapiens 
2016-01-07 | E-GEOD-64818 | biostudies-arrayexpress
GenomicsXist exploits three-dimensional chromosome architecture to spread across the X-chromosome
Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. Here we investigate the localization mechanisms of Xist during X-chromosome inactivation (XCI), a paradigm of lncRNA-mediated chromatin regulation. During the maint...
ORGANISM(S): Mus musculus 
2013-05-30 | E-GEOD-46918 | biostudies-arrayexpress
TranscriptomicsAn integrated 5'- and 3'-end RNA sequencing platform for high-throughput transcriptome quantitation and annotation
RNA-Seq provides an effective way to annotate and measure the transcriptome, but the combination of cost, analysis and end-mapping challenges has limited its adoption for high-throughput quantitation and annotation. Here, we present an integrated experimental and computational suite for transcriptom...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-47207 | biostudies-arrayexpress
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