Sort   by:  
 Page size 
TranscriptomicsExpression data for HIF1alpha-regulated genes in clear cell renal carcinoma cells (ccRCC)
Gene expression profiling was performed in ccRCC cells, which either express both HIF1alpha and HIF2alpha (either naturally or by virtue of induced expression of HIF1alpha) or express HIF2alpha alone (either naturally or by virtue of a HIF1alpha shRNA), to identify genes regulated by HIF1alpha in cc...
ORGANISM(S): Homo sapiens 
2011-12-02 | E-GEOD-27415 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from mice with constitutively active Hypoxia Inducible Factor (HIF-1a and HIF-2a) or inactivated von Hippel-Lindau tumor suppressor gene product (pVHL)
The effects of constitutively active Hypoxia Inducible Factor (HIF) and inactivated von Hippel-Lindau tumor suppressor gene product (pVHL) were examined in a mouse model. Conditionally expressed, constitutively active HIF-1a and HIF-2a were compared with inactivated pVHL.
ORGANISM(S): Mus musculus 
2006-09-21 | E-MEXP-856 | biostudies-arrayexpress
TranscriptomicsExpression data from Rbp2f/f and Rbp2-/- ES cells before and after differentiation
Aberrations in epigenetic processes, such as histone methylation, can lead to cancer. Retinoblastoma Binding Protein 2 (RBP2)(also called JARID1A or KDM5A) can demethylate tri- and di-methylated lysine 4 in histone H3, which are epigenetic marks for transcriptionally active chromatin, whereas the ME...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-26446 | biostudies-arrayexpress
TranscriptomicsTo identify genes responsive to treatment with the HIF2a inhibitor PT2399
HIF2a function is both necessary and sufficient for the growth of VHL-null clear cell Renal Cell Carcinoma (ccRCC). Targeting HIF2a function can therefore be a promising therapeutic strategy. We used microarray analysis to characterize a novel pharmacological inhibitor of HIF2a named PT2399. By comp...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-72959 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary embryonic fibroblasts reveals the retinoblastoma binding protein RBP2 is an H3K4 demethylase
The roles of histone demethylase RBP2 in gene expression were assessed using gene expression profiling experiments with wild type and RBP2-/- primary MEFs. Several cytokine genes including SDF1 and Kit ligand were upregulated upon inactivation of RBP2. Experiment Overall Design: Total RNA were extr...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6945 | biostudies-arrayexpress
TranscriptomicsHistone Demethylase JARID1B Controls Mammary Gland Development by Regulating Key Developmental Genes
The jmjC-domain containing H3K4 histone demethylase JARID1B/KDM5B/PLU1 is over-expressed in human breast cancer and is a potential target for breast cancer treatment. To investigate the in vivo function of JARID1B, we developed a new strain of Jarid1b knockout mice and characterized the phenotypes i...
ORGANISM(S): Mus musculus 
2014-05-19 | E-GEOD-50479 | biostudies-arrayexpress
GenomicsWhole Genomic Sequencing of Nine Primary Colorectal Adenocarcinoma Tumor/Germline Pairs

This study was the first-known effort to complete the complete genome sequencing of primary colorectal adenocarcinomas and the matched germline genome. Nine colorectal adenocarcinomas selected on the basis of having chromosomal instability were subjected to 'shotgun' Illumina sequencing w...

phs000374.v1.p1 | EGA
Sort   by:  
 Page size