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TranscriptomicsKainic acid-administered Rat brain: control vs Ketogenic diet-fed
The ketogenic diet has long been used to treat epilepsy, but its mechanism is not yet clearly understood. To explore the potential mechanism, the changes in gene expression induced by the ketogenic diet in the rat kainic acid (KA) epilepsy model were analyzed. Two-condition experiment, Normal diet-f...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-19277 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Rattus norvegicus brain hippocampal CA1 regions after kainic acid induced status epilepticus and untreated controls.
In this study we used microarray analysis to reveal the gene expression profile of the hippocampal CA1 subregion, which was laser-capture microdissected one week after kainic acid (KA)-induced status epilepticus (SE) in postnatal day 21 (P21) rats. These rats are developmentally roughly comparable t...
ORGANISM(S): Rattus norvegicus 
2010-10-25 | E-TABM-881 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of kainic acid-induced gene expression in dentate gyrus from CTR and SRF knockout mice.
To identify genes regulated by SRF in response to increased neuronal activity whole-genome expression profiling (Illumina Mouse WG-6 microarrays) of kainic acid-induced genes were performed. We found that loss of SRF in DG leads to specific deficits in activity-induced gene expression. Identified ge...
ORGANISM(S): Mus musculus 
2015-02-02 | E-GEOD-60772 | biostudies-arrayexpress
GenomicsGenome-wide analysis of histone H3K18 lactylation in a kainic acid-induced epilepsy model
Genome-wide analysis of histone H3K18 lactylation in a kainic acid-induced epilepsy model
PRJNA1442815 | ENA
TranscriptomicsRat MeDIP Array, naïve, epileptic, and adenosine treated
Epilepsy causes altered gene expression; transient adenosine treatment inhibits progression of epileptogenesis Hippocampus of epileptic rat is hypermethylated compared to naïve; adenosine treatment causes hypomethylation Metylation state in epileptic rats (9 weeks post kainic acid induced status epi...
ORGANISM(S): Rattus rattus 
2013-09-05 | E-GEOD-45932 | biostudies-arrayexpress
TranscriptomicsMicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells. [miRNA expression]
Temporal lobe epilepsy (TLE) can develop from alterations in hippocampal structure and circuit characteristics, and can be modeled in mice by administration of kainic acid (KA). Adult neurogenesis in the dentate gyrus (DG) contributes to hippocampal functions and has been reported to contribute to t...
ORGANISM(S): Mus musculus 
2016-03-12 | E-GEOD-79131 | biostudies-arrayexpress
TranscriptomicsKainic acid-administered Rat brain: control vs Ketogenic diet-fed
The ketogenic diet has long been used to treat epilepsy, but its mechanism is not yet clearly understood. To explore the potential mechanism, the changes in gene expression induced by the ketogenic diet in the rat kainic acid (KA) epilepsy model were analyzed.
ORGANISM(S): Rattus norvegicus 
2009-12-02 | GSE19277 | GEO
MetabolomicsATP-binding Cassette Sub-family C Member 5 (ABCC5) Functions as an Efflux Transporter of Glutamate Conjugates and Analogs
The ubiquitous efflux transporter ATP-binding cassette sub-family C member 5 (ABCC5) is present at high levels in the blood-brain barrier, neurons and glia, but its function is not known. Untargeted metabolomic screens revealed that Abcc5-/- mice accumulate endogenous glutamate conjugates in several...
2015-11-02 | MTBLS197 | MetaboLights
TranscriptomicsGenome-wide profiling of the activity-dependent hippocampal transcriptome
Activity-dependent gene expression is central for sculpting neuronal connectivity in the brain. Despite the importance for synaptic plasticity, a comprehensive analysis of the temporal changes in the transcriptomic response to neuronal activity is lacking. In a genome wide survey we identified genes...
ORGANISM(S): Mus musculus 
2013-10-23 | E-GEOD-49030 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of hippocampi of rats that were injected with kainic acid at postnatal day (P) 20 to induce early-life seizures and then housed in an enriched environment until P30
Neuropsychiatric consequences of poorly controlled seizures that begin in childhood can be devastating. School failure or behavioral difficulty in a child with epilepsy is common and can become the focus of concern for families. Current antiepileptic drugs compound problems with their CNS side effe...
ORGANISM(S): Rattus norvegicus 
2007-09-14 | E-GEOD-1833 | biostudies-arrayexpress
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