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TranscriptomicsBP001-002: The genomic landscape of compensatory evolution
Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, deleterious mutations may also have an important role by promoting adaptive genetic changes that are otherwise inaccessible. Here we study the capacity of the bakerM-bM-^@M-^Ys yeast genome...
ORGANISM(S): Saccharomyces cerevisiae BY4741 
2014-08-27 | E-GEOD-55373 | biostudies-arrayexpress
TranscriptomicsEvolution of robustness to protein mistranslation by accelerated protein turnover
To investigate how organisms mitigate the deleterious effects of mistranslation during evolution, a mutant tRNA was expressed in S. cerevisiae. The expression of Candida Ser-tRNACAG from a low copy plasmid in S. cerevisiae promoted mistranslation events by random incorporation of both serine and leu...
ORGANISM(S): Saccharomyces cerevisiae 
2015-11-06 | E-GEOD-65718 | biostudies-arrayexpress
TranscriptomicsDeciphering a functional gene network underlying robustness to protein overproduction
We systematically investigated the impact of genetic variation and the environment on protein overproduction costs in Saccharomyces cerevisiae To identify genes mediating protein overproduction costs, genetic perturbations were applied. The yEVenus overexpression plasmid was crossed into gene deleti...
ORGANISM(S): Saccharomyces cerevisiae 
2016-09-01 | E-GEOD-68753 | biostudies-arrayexpress
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