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MetabolomicsMetaboKit: a comprehensive data extraction tool for untargeted metabolomics (Mouse liver assays)

We have developed MetaboKit, a comprehensive software package for compound identification and relative quantification in mass spectrometry-based untargeted metabolomics analysis. In data dependent acquisition (DDA) analysis, MetaboKit constructs a customized spectral library with compound identit...

2021-11-02 | MTBLS1266 | MetaboLights
MetabolomicsMetaboKit: a comprehensive data extraction tool for untargeted metabolomics (Standard mixture assay)

We have developed MetaboKit, a comprehensive software package for compound identification and relative quantification in mass spectrometry-based untargeted metabolomics analysis. In data dependent acquisition (DDA) analysis, MetaboKit constructs a customized spectral library with compound identit...

2021-11-05 | MTBLS1311 | MetaboLights
TranscriptomicsDownregulation of Myc is essential for terminal erythroid maturation
Terminal differentiation of mammalian erythroid progenitors involves 4-5 cell divisions and induction of many erythroid important genes, followed by chromatin and nuclear condensation and enucleation. The protein levels of c-myc (Myc) are reduced dramatically during late stage erythroid maturation, ...
ORGANISM(S): Mus musculus 
2010-10-13 | E-GEOD-18558 | biostudies-arrayexpress
TranscriptomicsScaling of gene expression with liver cell size in vivo
A partially hepatectomized mouse liver with a liver-specific conditional Cdk1 knock-out genotype grows back to the normal size in the absence of cell divisions resulting in highly enlarged nuclear and cell size. This experiment analyses gene expression in four sets of mouse livers all with different...
ORGANISM(S): Mus musculus 
2014-03-06 | E-MTAB-1297 | biostudies-arrayexpress
ProteomicsK562 Chemical arrest cell cycle phase fractions 2D-MS-CETSA
K562 cells were synchronized by double thymidine block(DTB) based chemical arrest scheme into G1/S, S and Prometaphase(PM) fractions. Three biological replicates were collected on different days, and assembled into a 2D-CETSA scheme with 6 different heating temperatures (37ºC, 47ºC, 50ºC, 52ºC,54ºC ...
ORGANISM(S): Homo Sapiens (human) 
2018-05-08 | PXD009146 | JPOST Repository
ProteomicsK562 Elutriation cell cycle phase fractions 2D-MS-CETSA
K562 cells were synchronized by cell size difference based Elutriation scheme into G1, S and G2 fractions. Three biological replicates were collected on different days, and assembled into a 2D-CETSA scheme with 6 different heating temperatures (37ºC, 47ºC, 50ºC, 52ºC,54ºC and 57ºC), (Figure 1A, Meth...
ORGANISM(S): Homo Sapiens (human) 
2018-05-08 | PXD009171 | JPOST Repository
ProteomicsThe Greatwall kinase safeguards the genome integrity by balancing the kinome activity in mitosis.
Mastl is commonly overexpressed in cancer, appearing as an alternative therapeutic anticancer target. Loss of Mastl induces multiple chromosomal mitotic errors that lead to the accumulation of micronuclei and multilobulated cells with polyploidy. Our detailed analyses display that loss of Mastl quic...
ORGANISM(S): Mus Musculus (mouse) 
2020-10-15 | PXD019297 | JPOST Repository
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
TranscriptomicsGlycine decarboxylase is a metabolic oncogene critical for tumor initiating cells and tumorigenesis in lung cancer
New approaches to cancer therapies could benefit from a better understanding of the molecular determinants critical to tumor initiating cells (TICs). Here we show that the metabolic enzyme glycine decarboxylase (GLDC) is critical for TICs in non-small cell lung cancer (NSCLC). From a broad range ...
ORGANISM(S): Homo sapiens 
2011-10-25 | E-GEOD-33198 | biostudies-arrayexpress
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