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TranscriptomicsData integration from two microarray platforms identifies genetic inactivation of RIC8A in a breast cancer cell line
Using array comparative genomic hybridization (aCGH), a large number of deleted genomic regions have been identified in human cancers. However, subsequent efforts to identify target genes selected for inactivation in these regions have often been challenging. We integrated here genome-wide copy numb...
ORGANISM(S): Homo sapiens 
2010-06-19 | E-GEOD-15477 | biostudies-arrayexpress
GenomicsDual Role of FoxA1 in Androgen Receptor Binding to Chromatin, Androgen Signaling and Prostate Cancer [ChIP_seq, DHS_seq]
We report the dual role of FoxA1 in androgen receptor recruitment to the chromatin of androgen responsive prostate cancer cell line LNCaP-1F5 using ChIP-sequencing. Depletion of FoxA1 reprograms both androgen and glucocorticoid receptor recruitment and subsequent gene expression. The ChIP-seq has be...
ORGANISM(S): Homo sapiens 
2011-09-14 | E-GEOD-30623 | biostudies-arrayexpress
Genomicsena-DATASET-FIMM-19-02-2016-09:48:34:645-121 - samples
RNA sequence data for conditionally reprogrammed cells from patient HUB_5
EGAD00001001923 | EGA
GenomicsPatient-derived conditionally reprogrammed cells (CRCs) were established and characterized to assess their biological properties and to apply these to test the efficacies of drugs.
RNA seq data was used for the characterization and profiling of the created patient-derived cells and in vivo tissue.
EGAS00001001702 | EGA
TranscriptomicsIdentification of MicroRNAs Inhibiting TGF-beta-Induced IL-11 Production in Bone Metastatic Breast Cancer Cells
Identification of MicroRNAs Inhibiting TGF-beta-Induced IL-11 Production in Bone Metastatic Breast Cancer Cells
ORGANISM(S): Homo sapiens 
2012-11-22 | E-TABM-1220 | biostudies-arrayexpress
TranscriptomicsThe effect of miRNA overexpression on gene expression profile of MCF-7 cells
To identify microRNAs impacting estrogen receptor ERα expression in breast cancer, we have screened ER-positive breast cancer cells with a library of pre-miRs, and systematically monitored the ERα expression by protein lysate microarrays. There was a significant enrichment of the in silico predict...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14847 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of MCF7 breast cancer cells cultured as xenografts, in two dimensional cultures, in polyHEMA anchorage independent three dimansional cell culture models and in Matrigel three dimensional cultures.
The traditional method for studying cancer in vitro is to grow immortalized cancer cells in two-dimensional (2D) monolayers on plastic. However, many cellular features are impaired in these unnatural conditions and big alterations in gene expression in comparison to tumors have been reported. Three-...
ORGANISM(S): Homo sapiens 
2013-10-30 | E-GEOD-47583 | biostudies-arrayexpress
GenomicsOncogenic Herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication.
ChIP-sequencing reads from Oncogenic Herpesvirus utilizes stress-induced cell cycle checkpoints for efficient lytic replication, accepted to PLOS Pathogens
ORGANISM(S): Homo sapiens 
2016-06-01 | E-MTAB-4356 | biostudies-arrayexpress
TranscriptomicsHigh-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells.
The traditional method for studying cancer in vitro is to grow immortalized cancer cells in two-dimensional (2D) monolayers on plastic. However, many cellular features are impaired in these unnatural conditions and big alterations in gene expression in comparison to tumors have been reported. Three-...
ORGANISM(S): Homo sapiens 
2013-10-30 | E-GEOD-42529 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of the immortalized human endothelial cell lines HMEC-1 and TIME
The distinction between lymphatic and blood vessels is biologically fundamental. Two immortalized cell lines, which have been widely used as models for endothelial cells of blood vascular origin, are the human microvascular endothelial cell line-1 (HMEC-1) and the telomerase-immortalized microvascul...
ORGANISM(S): Homo sapiens 
2013-09-11 | E-GEOD-42216 | biostudies-arrayexpress
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