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ProteomicsIdentifying Compartment-specific Alloimmune Targets After Renal Transplantation by integrated genomics
Microarray technology has evolved as a powerful tool over the last decade, to identify biomarkers and study the mechanisms of diseases. We propose a novel application of integrated genomics by combining transcriptional levels with serological antibody profiling after kidney transplantation, with the...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10452 | biostudies-arrayexpress
TranscriptomicsLocal regulation and clinical impact of complement gene expression in deceased and living donor kidney allografts
The biopsy samples obtained at implantation segregated in 2 distinct groups according to donor origin, with a cluster of 319 unique identified genes higher expressed in DD compared to LD kidneys, and 329 genes lower expressed (false discovery rate <5%). Using pathway analysis software a significant ...
ORGANISM(S): Homo sapiens 
2008-04-16 | E-GEOD-11166 | biostudies-arrayexpress
TranscriptomicsInnate and adaptive immune responses associate with progressive histological damage of renal allografts
CONTEXT Slowly progressive chronic tubulo-interstitial damage jeopardizes long-term renal allograft survival. Both immune and non-immune mechanisms are thought to contribute, but the most promising targets for timely intervention have not been identified. OBJECTIVE In the current study we seek to de...
ORGANISM(S): Homo sapiens 
2011-12-10 | E-GEOD-25902 | biostudies-arrayexpress
TranscriptomicsThree non-invasive protein biomarkers for solid-organ transplant rejection found through integrative genomics
We integrated three transplant rejection microarray studies examining gene expression in samples from pediatric renal, adult renal, and adult heart transplants. We performed one study ourselves and retrieved two others from the NCBI Gene Expression Omnibus (GEO)(GSE4470 and GSE1563). We identified 4...
ORGANISM(S): Homo sapiens 
2010-10-12 | E-GEOD-14328 | biostudies-arrayexpress
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