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TranscriptomicsCharacterization of human malaria parasite Plasmodium falciparum eIF4E homologue and mRNA 5′ cap status
The mRNA 5′ cap is normally essential for eukaryotic mRNA translation, stabilization and transport and both the cap and eIF4E are important elements of post-transcriptional gene regulation. To further our understanding of mRNA translation in the human malaria parasite Plasmodium falciparum, we hav...
ORGANISM(S): Plasmodium falciparum 
2010-06-10 | E-GEOD-6356 | biostudies-arrayexpress
TranscriptomicsHard-wiring in the Plasmodium falciparum transcriptome I
To help malaria parasites survive unpredictable host immune responses, it is known that genes for surface proteins express stochastically in Plasmodium falciparum. Here, we demonstrate that gene expression for intracellular metabolic functions may be preordained and insensitive to specific metabolic...
ORGANISM(S): Plasmodium falciparum 
2008-11-14 | E-GEOD-9724 | biostudies-arrayexpress
MetabolomicsMechanisms of PfDNMT2 inhibition and PfATP6-mediated resistance to the antimalarial candidate SC83288 in Plasmodium falciparum

The emergence of multi-drug resistant Plasmodium falciparum underscores the urgent need for new antimalarial therapies. SC83288, a novel chemical entity, is highly effective against P. falciparum both in vivo and in vitro, including strains resistant to artemisinin and partner drugs. Here, we sho...

2026-02-16 | MTBLS13911 | MetaboLights
TranscriptomicsPyronaridine and chloroquine responses in the K1 strain
Pyronaridine (PN) and chloroquine (CQ) are structurally related anti-malarial drugs with primarily the same mode of action. However, PN is effective against several multidrug-resistant lines of Plasmodium falciparum, including CQ-resistant lines, suggestive of important operational differences betwe...
ORGANISM(S): Plasmodium falciparum 
2011-08-01 | E-GEOD-30867 | biostudies-arrayexpress
TranscriptomicsComparison of developmental stage transcripts in the K1 strain
To identify the developmentally regulated genes, which could confound identification of PN and CQ drug responsive genes, RNA samples from drug-free synchronized cultures from ring, trophozoite, and schizont stages were individually labelled and hybridized with a pooled sample from the three stages. ...
ORGANISM(S): Plasmodium falciparum 
2011-08-01 | E-GEOD-30869 | biostudies-arrayexpress
TranscriptomicsHard-wiring in the Plasmodium falciparum transcriptome 2
To help malaria parasites survive unpredictable host immune responses, it is known that genes for surface proteins express stochastically in Plasmodium falciparum. Here, we demonstrate that gene expression for intracellular metabolic functions may be preordained and insensitive to specific metabolic...
ORGANISM(S): Plasmodium falciparum 
2010-05-16 | E-GEOD-9853 | biostudies-arrayexpress
TranscriptomicsPlasmodium parasites mount an arrest response against dihydroartemisinin [Microarray]
Control of malaria is threatened by emerging parasite resistance to artemisinin drug (ART) therapies. The molecular details of how Plasmodium malaria parasites response to ART and how this relates to resistance is not clear. To determine how parasites respond to ART by altering gene expression, we p...
ORGANISM(S): Plasmodium falciparum 
2015-10-15 | E-GEOD-61536 | biostudies-arrayexpress
TranscriptomicsHard-wiring in the Plasmodium falciparum transcriptome II
To help malaria parasites survive unpredictable host immune responses, it is known that genes for surface proteins express stochastically in Plasmodium falciparum. Here, we demonstrate that gene expression for intracellular metabolic functions may be preordained and insensitive to specific metabolic...
ORGANISM(S): Plasmodium falciparum 
2010-05-16 | E-GEOD-9868 | biostudies-arrayexpress
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