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GenomicsR-loops induce repressive chromatin marks over mammalian gene terminators
The formation of R-loops is a natural consequence of the transcription process, caused by invasion of the DNA duplex by nascent transcripts. These structures have been considered rare transcriptional by-products with potential harmful effects on genome integrity, due to the fragility of the displace...
ORGANISM(S): Homo sapiens 
2014-09-29 | E-GEOD-59878 | biostudies-arrayexpress
TranscriptomicsThe genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells
We employed the DamID technique to systematically map the genomic distribution of all canonical somatic H1 subtypes (H1.1-H1.5) in human IMR90 cells. Human cells contain up to eleven histone H1 proteins, with different spatial and temporal expression patterns. These include five canonical, replicati...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-40886 | biostudies-arrayexpress
TranscriptomicsHuman nuclear Dicer restricts the deleterious accumulation of endogenous double strand RNA
Dicer is a central enzymatic player in RNA interference (RNAi) pathways that acts to regulate gene expression in nearly all eukaryotes. Although the cytoplasmic function of Dicer is well documented in mammals, there is little known about any possible nuclear function. Here we show that Dicer is pre...
ORGANISM(S): Homo sapiens 
2014-04-10 | E-GEOD-56648 | biostudies-arrayexpress
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