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TranscriptomicsMicroRNA expression data in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is an untreatable fibrotic lung disease characterized by fibroblast proliferation and epithelial mesenchymal transition. Using miRNA expression microarrays we identified 96 differentially expressed miRNA in IPF lungs which included let-7d, miR-30 family, miR-29 fa...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-27430 | biostudies-arrayexpress
TranscriptomicsMouse conjunctival forniceal gene expression during postnatal development and its regulation by Kruppel-like factor 4
Purpose: To identify the changes in postnatal mouse conjunctival forniceal gene expression and their regulation by Klf4 around eye opening stage when the goblet cells first appear. Methods: Laser-capture-microdissection was used to collect conjunctival forniceal epithelial cells from postnatal-day (...
ORGANISM(S): Mus musculus 
2011-06-15 | E-GEOD-26076 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profile of platelets in sickle cell disease
Circulating platelets from Sickle cell disease (SCD) patients express distinct gene expression patterns that regulate function. The objective of this study is to identify a role of post-transcriptional regulation of the platelet transcriptional signaling by microRNAs. Comparison of microRNA expressi...
ORGANISM(S): Homo sapiens 
2013-06-20 | E-GEOD-41574 | biostudies-arrayexpress
TranscriptomicsGene expression in lung fibroblasts
Pulmonary fibrosis is a chronic, progressive, and lethal interstitial lung disease. It is characterized by extracellular matrix deposition, fibroblast proliferation, and accumulation. Fibroblasts from normal or UIP histology were cultured and analyzed. Keywords: Fibroblasts from normal histology lun...
ORGANISM(S): Homo sapiens 
2010-06-21 | E-GEOD-10921 | biostudies-arrayexpress
TranscriptomicsGene expression data in Mouse Lung Epithelial cells MLE-12 transfected with inhibitors and precursors for miR-30a, miR-30d, miR-23b, miR-125 and miR-337, miR-466a, miR466d, miR-476c, respectively
The regulation of gene expression in cells, including by microRNAs (miRNAs), is a dynamic process. Current methods for identifying microRNA targets by combining sequence, miRNA and mRNA expression data do not adequately utilize the temporal information and thus miss important miRNAs and their target...
ORGANISM(S): Mus musculus 
2013-10-18 | E-GEOD-41607 | biostudies-arrayexpress
TranscriptomicsGlobal Methylation Patterns in Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis (IPF) is a chronic progressive lung disease that affects more than 5 million people worldwide with a steady increase in both incidence and mortality. There is currently no effective therapy and the median survival without transplant is 2-5 years. The etiological factor ...
ORGANISM(S): Homo sapiens 
2012-04-18 | E-GEOD-29895 | biostudies-arrayexpress
TranscriptomicsGene expression data in mouse fetal lungs
Microarray data of mouse postnatal lungs between day 1 and 6 weeks of age. The results provide a general insight into the gene expression profile during the alveolar phase of lung development. We obtained lung tissue of healthy postnatal mice, 4-5 replicates at each time point. Time points were day1...
ORGANISM(S): Mus musculus 
2013-09-03 | E-GEOD-41412 | biostudies-arrayexpress
TranscriptomicsAsthma III
Bronchial Epithelial Cells were isolated processed as described (Chu et al., 2002 and Zhao et al., 2011). The objective of the study was to identify differentially expressed genes between normal control (NC), mild-moderate asmathic (notSA) and severe asthmatic (SA) patients. For demographics data,...
ORGANISM(S): Homo sapiens 
2015-10-27 | E-GEOD-67940 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse lung treated with saline or bleomycin
Lung fibrosis represents the final common pathway of a variety of lung injuries, and it is characterized, independently of etiology, by the expansion of the fibroblast/myofibroblast population and by the abnormal accumulation of extracellular matrix (ECM) replacing normal functional parenchyma. In g...
ORGANISM(S): Mus musculus 
2013-03-11 | E-GEOD-42301 | biostudies-arrayexpress
TranscriptomicsClara cell regulation of the inflammatory response
Chronic lung diseases are marked by excessive inflammation and epithelial remodeling. Reduced Clara cell secretory function and corresponding decreases in the abundance of the major Clara cell secreted protein, CCSP, are characteristically seen in these disease states. We sought to define the impact...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-16409 | biostudies-arrayexpress
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