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TranscriptomicsRole and function of Bach2 in BCR-ABL1 driven pre-B ALL
In order to investigate the function of Bach2 in pre-B ALL, we isolated bone marrow cells from wildtype and Bach2 knockout mice of C57Bl6 background and transformed them with BCR-ABL1. We compared the gene expression profiles of Bach2 wildtype and knockout pre-B ALL cells, both with and without ima...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-30883 | biostudies-arrayexpress
TranscriptomicsGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib). BCR-ABL1 t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20987 | biostudies-arrayexpress
TranscriptomicsEffect of Bach2 overexpression in BCL6+/+ and -/- BCR-ABL1 transformed pre-B cells
The aim was to investigate how BCL6 genotype affects Bach2 dependent gene expression changes. We compared gene expression profiles of BCL6+/+ and BCL6-/- BCR-ABL1 transformed pre-B cells after inducible overexpression of Bach2.
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-41042 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
TranscriptomicsSaccharomyces cerevisiae BY4741 cells treated with n-alkanes
Transcripitonal profiling of Saccharomyces cerevisiae treated with 2% n-alkanes vs untreatment Multiple condition experiment, S. cerevisiae treated with n-alkanes (n-nonane, n-decane, n-undecane, n-dodecane, respectively) for 24hrs or 48hrs, compared to control (those without treatment)
ORGANISM(S): Saccharomyces cerevisiae 
2015-04-07 | E-GEOD-38653 | biostudies-arrayexpress
TranscriptomicsUC San Diego Friedmann Kang Neuronal Differentiation DSD3 SNM
The gene expression pattern of spherical neural masses (SNM) derived from HPRT knockdown murine D3 stem cells during neuronal differentiation to final neurons was invesitigated by RNA-Seq based gene expression analysis and the results were interpreted by GO, GSEA and signaling pathway analyses with ...
ORGANISM(S): Mus musculus 
2012-12-10 | E-GEOD-42662 | biostudies-arrayexpress
TranscriptomicsExpression data from cynosure (cyn) mutant and its CYNOSURE (CYN) wild-type at before flowering and 5 days after pollination stage
To assess further the role of CYN in relation to integument morphogenesis, gametophytic cell fate specification, embryogenesis and endosperm development, we compared the expression profiles between the cyn mutant and wild-type at two different stages(before flowering and 5 days after pollination sta...
ORGANISM(S): Oryza sativa Japonica Group 
2014-11-03 | E-GEOD-33441 | biostudies-arrayexpress
GenomicsCharacterizing the profiles of Ebf1 in mouse fat cells (ChIP-seq)
ChIP-seq data from mouse adipocyte. Mature 3T3-L1 adipocytes were cross-linked with 1% formaldehyde 10 days after induction with MDI. Frozen cell pellets were submitted to the Broad Institute for subsequent analysis of Ebf1-bound regions using anti-Ebf1 antibody (Abnova H00001879-M01).
ORGANISM(S): Mus musculus 
2014-06-10 | E-GEOD-58330 | biostudies-arrayexpress
TranscriptomicsEscherichia coli K-12: luxS mutant LW12 vs. wild type W3110
Transcripitonal profiling of Escherichia coli K-12 comparing luxS mutant LW12 with wild type W3110 One-condition experiment, luxS mutant LW12 vs. wild type W3110
ORGANISM(S): Escherichia coli 
2010-11-11 | E-GEOD-20606 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of Hansenula polymorpha in response to sulfur starvation and cadmium stress
Transcriptome profiling analysis of the Hansenula polymorpha MET4 gene deletion strain have been carried out to obtain comprehensive information on the HpMet4p-mediated regulatory networks in association with the cadmium (Cd) detoxification and sulfur regulation in H. polymorpha. Total RNA samples w...
ORGANISM(S): Ogataea angusta 
2014-07-31 | E-GEOD-31197 | biostudies-arrayexpress
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