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TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of CD4+ T lymphocytes in response to an irradiation dose of 1 Gy.radiation
Differences in radiosensitivity existing among cells which constitute the lymphocyte population have been known for a long time, although the molecular basis of this differential radiation sensitivity remains unclear. In an attempt to get more insight into the molecular mechanisms leading to radiati...
ORGANISM(S): Homo sapiens 
2005-12-31 | E-MEXP-320 | biostudies-arrayexpress
UnknownHistone Lys demethylase KDM3C demonstrates anti-inflammatory effects by suppressing NF-κB signaling and osteoclastogenesis.
Not available
S-EPMC6704463 | biostudies-literature
TranscriptomicsIntegrative AUF1 PAR-CLIP analysis uncovers AUF1 roles in translation and genome integrity (PAR-CLIP)
We report that AUF1 modulates global mRNA stability and translation, in turn promoting the maintenance of DNA integrity. Please see individual series. In short, for AUF1 PAR-CLIP, the four isoforms of AUF1 (p37, p40, p42, and p45) tagged with a Flag epitope were expressed in HEK293 cells. For total ...
ORGANISM(S): Homo sapiens 
2014-11-05 | E-GEOD-52971 | biostudies-arrayexpress
Unknownα-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.
Not available
S-EPMC3346117 | biostudies-literature
UnknownContemporary Statistics of Acute Ischemic Stroke and Transient Ischemic Attack in 2021: Insights From the CRCS-K-NIH Registry.
Not available
S-EPMC11372415 | biostudies-literature
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Untargeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7840 | MetaboLights
UnknownVirtual visits for Parkinson disease: A multicenter noncontrolled cohort.
Not available
S-EPMC5566796 | biostudies-literature
TranscriptomicsIntegrative AUF1 PAR-CLIP analysis uncovers AUF1 roles in translation and genome integrity
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-52977 | biostudies-arrayexpress
UnknownBlockage of EGFR/AKT and mevalonate pathways synergize the antitumor effect of temozolomide by reprogramming energy metabolism in glioblastoma.
Not available
S-EPMC10693308 | biostudies-literature
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