Transcription profiling of CD4+ T lymphocytes in response to an irradiation dose of 1 Gy.radiation

ABSTRACT: Differences in radiosensitivity existing among cells which constitute the lymphocyte population have been known for a long time, although the molecular basis of this differential radiation sensitivity remains unclear. In an attempt to get more insight into the molecular mechanisms leading to radiation effects, we used microarray analysis to study transcriptional changes in CD4+ T lymphocytes to an irradiation dose of 1 Gy. The contribution of the cell type to the radiation response of CD4+ lymphocytes was deduced by comparing our results with a gene expression profile observed in Peripheral Blood Lymphocytes published by other groups (Amundson, 2000; Kang, 2003, Jen, 2003).

ORGANISM(S): Homo sapiens

SUBMITTER: M. Benotmane 

PROVIDER: E-MEXP-320 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress