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ProteomicsDevelopment of next-generation retinoid pathway immunotherapeutics through targeting tumor ALDH1a3
Aldehyde dehydrogenase (ALDH1) activity has long been established as a pro-tumorigenic feature of many cancers, yet the identification of specific isoforms that are enriched in cancer, the mechanism of action of this isoform(s), and viable therapeutic strategies to target this pathway have long rema...
ORGANISM(S): Homo sapiens (Human) 
2025-08-26 | PXD052693 | Pride
Human cancer Aldh inhibitors Cancer immunotherapy Retinoid antagonist 
TranscriptomicsHypoxia response by human breast cancer cell MDA-MB-231 sublines
Two MDA-MB-231 sublines, SCP2 and LM2 (4175), were applied to low oxygen (1%) for 0, 6 and 24 hours, then profiled for RNA expression. Two sublines, each sublines has three conditions: 0h, 6h and 24h for hypoxia treatment. Each condition has two repeats. Total 12 samples
ORGANISM(S): Homo sapiens 
2010-06-16 | E-GEOD-17188 | biostudies-arrayexpress
TranscriptomicsHuman breast cancer LM2 cell lines: control vs. MTDH knockdown
Transcriptional profiling of human breast cancer cell line LM2, a subline of MDA-MB-231 highly metastatic to lung when injected to nude mice, to identify the genes that are regulated after the metastasis gene metadherin is knocked down. Keywords: Genetic modification Empty pSuper vector control cell...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-9187 | biostudies-arrayexpress
UnknownMetabolomics analysis of five cultivars of Sorghum bicolor reveals the contribution of flavonoid pathway to tannin content.
Not available
S-EPMC11981146 | biostudies-literature
UnknownOverexpression of Sirt3 inhibits lipid accumulation in macrophages through mitochondrial IDH2 deacetylation.
Not available
S-EPMC4583898 | biostudies-literature
UnknownMetagenomic insights into short-term legume rotation: modulating potato rhizosphere microbiota to enhance tuber yield and quality.
Not available
S-EPMC12847424 | biostudies-literature
UnknownHIV-1 genetic transmission networks among people living with HIV/AIDS in Sichuan, China: a genomic and spatial epidemiological analysis.
Not available
S-EPMC8669382 | biostudies-literature
UnknownQuantitative analysis of macular and optic disc microvascular parameters in patients with immunoglobulin A nephropathy using optical coherence tomography angiography.
Not available
S-EPMC12397639 | biostudies-literature
OtherSirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity.
Data from ProteomeXchange, PXD ID: PXD001447. Experiment: SIRT4_MITO_MOCK1, file: SIRT4_MITO_MOCK1_05.mzml. Published as part of Cell. 2014 Dec 18;159(7):1615-25 . From the Abstract: {{i}} ... Here, we establish SIRT4 as a cellular lipoamidase that regulates the pyruvate dehydrogenase complex (PDH)...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320006423 | GPMDB
Resource Reanalysis 
ProteomicsAP-MS analysis of sirtuin-4 interactions in human fibroblasts
Sirtuins (SIRTs) form a critical family of nicotinamide adenine dinucleotide (NAD)-dependent enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, SIRTs4-7 have little to no deacetylase activity, and a robust catalytic activity for mitochondrial SIRT4 h...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-04 | MSV000079557 | MassIVE
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