Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse heart myocardium after a single dose administration of Isoproterenol hydrochloride
Gene expression was evaluated in the myocardium of male Wistar rats after a single sc administration of 0.5 mg of isoproterenol, a β-adrenergic agonist that causes acute tachycardia with subsequent myocardial necrosis. Histology of the heart, clinical chemistry and hematology were evaluated at 9 ti...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7999 | biostudies-arrayexpress
TranscriptomicsCardiac Effects of Rosiglitazone in Male Wistar Rats
Rosiglitazone, a peroxisome proliferator-activated receptor g (PPARg) agonist of the thiazolidinedione class, is a major insulin-sensitizing drug widely used to treat type-2 diabetes. Rosiglitazone causes myocardial hypertrophy in rodents and increases the risk of cardiac events in man. To better ...
ORGANISM(S): Rattus norvegicus 
2010-07-29 | E-GEOD-22553 | biostudies-arrayexpress
TranscriptomicsCardiotoxicity of tubulin binders
The use of tubulin binders (TBs) in oncology indications often is associated with cardiotoxicity, the mechanism of which has not been elucidated. We observed that a single administration of TBs to rats caused an increase in the number of mitotic figures in the myocardial interstitium after 24 hours...
ORGANISM(S): Rattus norvegicus 
2010-01-01 | E-GEOD-19290 | biostudies-arrayexpress
Sort   by:  
 Page size