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ProteomicsiTARGEX analysis of yeast deletome reveals novel regulators of transcriptional buffering in S phase and protein turnover
Integrating omics data with quantification of biological traits provides unparalleled opportunities for discovery of genetic regulators by in silico inference. However, current approaches to analyze genetic-perturbation screens are limited by their reliance on annotation libraries for prioritization...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-10 | PXD024258 | Pride
Itargex Protein turnover Transcriptional buffering 
GenomicsThe SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription [Yeast cells]
The SAGA co-activator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes. Surprisingly, recent studies revealed little overlap between genome-wide SAGA-binding profiles and changes in gene expression upon ...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-29 | E-GEOD-52997 | biostudies-arrayexpress
GenomicsThe SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription [HeLa cells]
The SAGA co-activator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes. Surprisingly, recent studies revealed little overlap between genome-wide SAGA-binding profiles and changes in gene expression upon ...
ORGANISM(S): Homo sapiens 
2014-08-29 | E-GEOD-52860 | biostudies-arrayexpress
UnknownActivation of CISD2 as a protective strategy against doxorubicin-induced cardiotoxicity.
Not available
S-EPMC12409322 | biostudies-literature
TranscriptomicsH2B mono-ubiquitylation facilitates fork stalling and recovery during replication stress by coordinating Rad53 activation and chromatin assembly
The influence of mono-ubiquitylation of histone H2B (H2Bub) on transcription via nucleosome reassembly has been widely documented. Recently, it has also been shown that H2Bub promotes recovery from replication stress; however, the underling molecular mechanism remains unclear. Here, we show that H2B...
ORGANISM(S): Saccharomyces cerevisiae 
2014-09-12 | E-GEOD-61030 | biostudies-arrayexpress
UnknownLow-Density Lipoprotein Cholesterol and Mortality in Patients With Intracerebral Hemorrhage in Taiwan.
Not available
S-EPMC8802633 | biostudies-literature
UnknownTwo Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
Not available
S-EPMC10794000 | biostudies-literature
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