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UnknownIndoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity.

Background & aims

Chronic gastrointestinal inflammation increases the risk of cancer by mechanisms that are not well understood. Indoleamine-2,3-dioxygenase 1 (IDO1) is a heme-binding enzyme that regulates the immune response via catabolization and regulation of tryptophan availability for i...
S-EPMC5742059 | biostudies-literature
UnknownKidney Recovery and Death in Critically Ill Patients With COVID-19-Associated Acute Kidney Injury Treated With Dialysis: The STOP-COVID Cohort Study.

Rationale & objective

Acute kidney injury treated with kidney replacement therapy (AKI-KRT) occurs frequently in critically ill patients with coronavirus disease 2019 (COVID-19). We examined the clinical factors that determine kidney recovery in this population.

Study design

Multicent...
S-EPMC8641974 | biostudies-literature
UnknownAssociation of Surge Conditions with Mortality Among Critically Ill Patients with COVID-19.

Objective

To determine whether surge conditions were associated with increased mortality.

Design

Multicenter cohort study.

Setting

U.S. ICUs participating in STOP-COVID.

Patients

Consecutive adults with COVID-19 admitted to participating ICUs between March 4 and July 1, ...
S-EPMC8926920 | biostudies-literature
UnknownModulation of the Association Between Age and Death by Risk Factor Burden in Critically Ill Patients With COVID-19.
Older age is a key risk factor for adverse outcomes in critically ill patients with COVID-19. However, few studies have investigated whether preexisting comorbidities and acute physiologic ICU factors modify the association between age and death.

Design

Multicenter cohort study.

Setting

S-EPMC9426819 | biostudies-literature
UnknownIdentification of Distinct Clinical Subphenotypes in Critically Ill Patients With COVID-19.

Background

Subphenotypes have been identified in patients with sepsis and ARDS and are associated with different outcomes and responses to therapies.

Research question

Can unique subphenotypes be identified among critically ill patients with COVID-19?

Study design and methods

U...
S-EPMC8099539 | biostudies-literature
UnknownPerformance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States.
Many US states published crisis standards of care (CSC) guidelines for allocating scarce critical care resources during the COVID-19 pandemic. However, the performance of these guidelines in maximizing their population benefit has not been well tested. In 2,272 adults with COVID-19 requiring mechani...
S-EPMC8316067 | biostudies-literature
UnknownAKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19.

Background

AKI is a common sequela of coronavirus disease 2019 (COVID-19). However, few studies have focused on AKI treated with RRT (AKI-RRT).

Methods

We conducted a multicenter cohort study of 3099 critically ill adults with COVID-19 admitted to intensive care units (ICUs) at 67 hos...
S-EPMC7894677 | biostudies-literature
UnknownOutcomes of critically ill solid organ transplant patients with COVID-19 in the United States.
National data on patient characteristics, treatment, and outcomes of critically ill coronavirus disease 2019 (COVID-19) solid organ transplant (SOT) patients are limited. We analyzed data from a multicenter cohort study of adults with laboratory-confirmed COVID-19 admitted to intensive care units (I...
S-EPMC7460925 | biostudies-literature
UnknownGenetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication...
S-EPMC4735748 | biostudies-literature
UnknownSearch for supersymmetry in pp collisions at [Formula: see text] TeV in events with a single lepton, jets, and missing transverse momentum.
Results are reported from a search for new physics processes in events containing a single isolated high-transverse-momentum lepton (electron or muon), energetic jets, and large missing transverse momentum. The analysis is based on a 4.98 fb-1 sample of proton-proton collisions at a cente...
S-EPMC4370766 | biostudies-literature
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