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TranscriptomicsTranscription profiling by array of human HL-60 cells treated with anacardic acid
The aim of the experiment was to identify the genes up or downregulated by hyposumoylation induced by anacardic acid, an inhibitor of SUMO activating enzyme, in Acute Myeloid Leukemia cell line HL-60
ORGANISM(S): Homo sapiens 
2014-06-11 | E-MTAB-2382 | biostudies-arrayexpress
TranscriptomicsComprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of Glioblastoma
The aim of the experiment was to identify the genes up or downregulated by short term (12 hours) and long term (7 days) severe hypoxia (0.1% O2) in glioblastoma cells
ORGANISM(S): Homo sapiens 
2015-11-30 | E-MTAB-3082 | biostudies-arrayexpress
TranscriptomicsAnalysis of glioblastoma tumor cell-specific gene expression profiles of distinct histological phenotypes
Here, we analyzed patient-derived glioblastoma xenografts generated in the mouse brain that give rise to three different histological phenotypes: (i) a highly invasive phenotype (ii) a highly angiogenic phenotype and (iii) an intermediate phenotype. Cell type-specific transcriptomic profiles of tumo...
ORGANISM(S): Mus musculus 
2016-06-30 | E-MTAB-3949 | biostudies-arrayexpress
TranscriptomicsAnalysis of glioblastoma tumor cell-specific gene expression profiles of distinct histological phenotypes
Here, we analyzed patient-derived glioblastoma xenografts generated in the mouse brain that give rise to three different histological phenotypes: (i) a highly invasive phenotype (ii) a highly angiogenic phenotype and (iii) an intermediate phenotype. Cell type-specific transcriptomic profiles of tumo...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-MTAB-3948 | biostudies-arrayexpress
TranscriptomicsNeutrophil-derived pro-inflammatory cytokine response and degranulation in function of time and dose of LPS treatment.
The purpose of the present study was to elucidate in more details the molecular mechanisms of neutrophil-mediated inflammation. We therefore investigated the time-dependent stimulatory potential of LPS from Escherichia coli on cytokine response in neutrophil-like HL-60 cells.

To get a genera...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-MTAB-1393 | biostudies-arrayexpress
TranscriptomicsIsocitrate dehydrogenase 1 mutations prime the all-trans-retinoic acid myeloid differentiation pathway in acute myeloid leukemia HL-60 cells
Human acute myeloid leukemia HL60 cells were transduced with IDH1-WT or IDH1-R132H, and corresponding sub-clones were generated by FACS. In a first series of experiments, cells expressing wt and mutant IDH1were treated with either 1µM all-trans retinoic acid (ATRA) or with vehicle (DMSO) for 24 hrs...
ORGANISM(S): Homo sapiens 
2017-03-01 | E-MTAB-4327 | biostudies-arrayexpress
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