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TranscriptomicsExpression analysis of C. elegans wild-type N2 and rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutants
Investigation of whole genome gene expression level changes in C. elegans rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutant compared to the wild-type N2 strain. The mutants have altered longevity phenotypes. The mutants analyzed in this study are further described in Di Chen, Patrick Wai-...
ORGANISM(S): Caenorhabditis elegans 
2013-11-14 | E-GEOD-52340 | biostudies-arrayexpress
TranscriptomicsInsulin-like Signaling Determines Survival During Stress via Post Transcriptional Mechanisms in C. elegans.
The insulin-like signaling (ILS) pathway regulates metabolism and is known to modulate adult lifespan in C. elegans. Altered stress responses and resistance to a wide range of stressors are also associated with changes in ILS and contribute to enhanced longevity. The transcription factors DAF-16 and...
ORGANISM(S): Caenorhabditis elegans 
2010-06-17 | E-GEOD-22383 | biostudies-arrayexpress
TranscriptomicsLate life rapamycin treatment reverses age-related heart dysfunction
We report the mRNA profile of aged mice (24 months old) fed either a control diet or a diet containing Rapamycin (14 ppm) for 3 months. After drug treatement, the hearts of the mice were removed and total mRNA was removed from the tissue. Analysis revealed that there were 700 significantly different...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-48043 | biostudies-arrayexpress
TranscriptomicsLifespan extension via eIF4G inhibition is mediated by post-transcriptional remodeling of stress response gene expression in C. elegans
Reducing protein synthesis slows growth and development but can increase adult lifespan. We demonstrate that knock-down of eukaryotic translation initiation factor 4G (eIF4G), which is down-regulated during starvation, results in differential translation of genes important for growth and longevity i...
ORGANISM(S): Caenorhabditis elegans 
2011-04-16 | E-GEOD-28665 | biostudies-arrayexpress
TranscriptomicsIntra-myocellular fatty acid synthesis and breakdown plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster
Dietary restriction (DR) is a robust environmental intervention that slows aging in various species. Changes in fat content have been associated with DR, but whether they play a causal role in mediating various responses to DR remains unknown. We demonstrate that upon DR, Drosophila melanogaster shi...
ORGANISM(S): Drosophila melanogaster 
2012-06-14 | E-GEOD-37537 | biostudies-arrayexpress
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