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TranscriptomicsKRAB/KAP1-microRNA cascade regulates erythropoiesis through the stage-specific control of mitophagy
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-44065 | biostudies-arrayexpress
TranscriptomicsRNA-seq and expression profile of WT and ZFP57 KO ES cells
RNA-seq and expression profile of WT and ZFP57 KO ES cells RNA was extracted from both cell lines, PolyA RNA were extracted and RNA-seq was performed
ORGANISM(S): Mus musculus 
2011-11-07 | E-GEOD-31182 | biostudies-arrayexpress
GenomicsChIP-Seq of HA tagged ZFP57 and KAP1 in mouse ES cells
We have performed ChIP seq analysis to obtain the positions of KAP1 and ZFP57 binding sites in mouse ES cells. By comparing the two lists, we were able to find bona fide sites. ChIP-Seq of HA tagged ZFP57 and KAP1 in mouse ES cells
ORGANISM(S): Mus musculus 
2011-11-07 | E-GEOD-31181 | biostudies-arrayexpress
TranscriptomicsKRAB/KAP1-microRNA cascade regulates erythropoiesis through the stage-specific control of mitophagy [array]
A multilayered transcription regulatory system is unveiled, where protein- and RNA-based repressors are super-imposed in combinatorial fashion to govern the timely triggering of an essential step of erythropoiesis Analyses of transcriptional profiles and chromatin state in KAP1 WT and KO cells
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-44063 | biostudies-arrayexpress
TranscriptomicsKRAB/KAP1-microRNA cascade regulates erythropoiesis through the stage-specific control of mitophagy [Seq]
A multilayered transcription regulatory system is unveiled, where protein- and RNA-based repressors are super-imposed in combinatorial fashion to govern the timely triggering of an essential step of erythropoiesis Analyses of transcriptional profiles and chromatin state in KAP1 WT and KO (or KD) ce...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-44061 | biostudies-arrayexpress
TranscriptomicsTRIM28 silences endogenous retroviruses in neural progenitor cells
Here we show that in neural progenitor cells (NPCs) TRIM28 silences transcription of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. Derepression of ERVs in Trim28-deficient NPCs was associated with a loss of H3K9me3 and resulted in transcriptional upregulation and reverse transcri...
ORGANISM(S): Mus musculus 
2015-01-07 | E-GEOD-45930 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of wild type and KAP1 KO mouse T cell progenitors
The modulation of chromatin status at specific genomic loci controls lymphoid differentiation. Here, we investigated the role played in this process by KAP1, the universal cofactor of KRAB-containing Zinc Finger Proteins (KRAB-ZFPs), a tetrapod-restricted family of transcriptional repressors. T cell...
ORGANISM(S): Mus musculus 
2012-12-16 | E-GEOD-34447 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of wild type and KAP1 KO splenic B cells
Chromatin remodeling is fundamental for B cell differentiation. Here, we explored the role in this process of KAP1, the cofactor of KRAB-ZFP transcriptional repressors. B lymphoid-specific Kap1 knockout mice displayed reduced numbers of mature B cells, lower steady-state levels of antibodies and acc...
ORGANISM(S): Mus musculus 
2012-05-16 | E-GEOD-34446 | biostudies-arrayexpress
GenomicsChIP-seq analysis of KAP1 binding and H3K9me3 modifications in mouse T cell progenitors
Chromatin remodelling at specific genomic loci controls lymphoid differentiation. Here, we investigated the role played in this process by Kruppel-Associated Box (KRAB)- Associated Protein 1 (KAP1), the universal cofactor of KRAB-zinc finger proteins (-ZFPs), a tetrapod-restricted family of transcri...
ORGANISM(S): Mus musculus 
2012-12-16 | E-GEOD-38579 | biostudies-arrayexpress
GenomicsChIP-seq analysis of KAP1 and H3K9me3 modifications in mouse spleen B cells
Chromatin remodeling is fundamental for B cell differentiation. Here, we explored the role in this process of KAP1, the cofactor of KRAB-ZFP transcriptional repressors. B lymphoid-specific Kap1 knockout mice displayed reduced numbers of mature B cells, lower steady-state levels of antibodies and acc...
ORGANISM(S): Mus musculus 
2012-05-16 | E-GEOD-36850 | biostudies-arrayexpress
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