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TranscriptomicsDeciphering the relationship between polycomb repression and stochastic gene expression from single-cell RNA-seq data
Polycomb repressive complexes are important histone modifiers, which silence gene expression, yet there exists a subset of polycomb-bound genes actively transcribed by RNA polymerase II. To investigate the switching between polycomb-repressed and active states, we sequence mRNA from OS25 mouse embry...
ORGANISM(S): Mus musculus 
2017-06-01 | E-MTAB-5661 | biostudies-arrayexpress
TranscriptomicsTh2 differentiation in a time course experiment and at single generation resolution
Mouse splenic naïve T cells were activated (with anti-CD3/CD28)and polarized towards the Th2 subtype with IL4 . Cells were collected at different time points during the differentiation and, at day 3 .5,were collected according to number of cell divisions and expression or absence of a specific diff...
ORGANISM(S): Mus musculus 
2016-04-01 | E-MTAB-3543 | biostudies-arrayexpress
TranscriptomicsEffect of the IRE1a-XBP1 pathway inhibition during T helper 2 differentiation
The purpose of the study was to examine the role of the IRE1a-XBP1 pathway during Th2 lymphocyte activation and differentiation. In vitro Th2 cells were treated with 4μ8c, a drug that specifically inhibits IRE1a endonuclease activity, and transcriptomes were compared.
ORGANISM(S): Mus musculus 
2018-07-20 | E-MTAB-6894 | biostudies-arrayexpress
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