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MetabolomicsDeletion of glycerol channel aquaporin-9 (Aqp9) impairs long-term blood glucose control in C57BL/6 leptin receptor-deficient (db/db) obese mice
Deletion of the glycerol channel aquaporin-9 (Aqp9) reduces postprandial blood glucose levels in leptin receptor deficient (db/db) obese mice on a C57BL/6×C57BLKS mixed genetic background. Furthermore, shRNA mediated reduction of Aqp9 expression reduces liver triacylglycerol (TAG) accumulation in a ...
2015-09-28 | MTBLS219 | MetaboLights
TranscriptomicsMicrocolony formation by the opportunistic pathogen Pseudomonas aeruginosa requires pyruvate and pyruvate fermentation.
A hallmark of the biofilm architecture is the presence of microcolonies. However, little is known about the underlying mechanisms governing microcolony formation. In the human pathogen Pseudomonas aeruginosa, microcolony formation is dependent on the two-component regulator MifR, with mifR mutant bi...
ORGANISM(S): Pseudomonas aeruginosa 
2012-04-30 | E-GEOD-35286 | biostudies-arrayexpress
TranscriptomicsPseudomonas aeruginosa two-component regulator BfmR controls bacteriophage lysis and DNA release during biofilm development through PhdA
Biofilms are surface-adhered bacterial communities encased in an extracellular matrix composed of polysaccharides, proteins, and extracelluar (e)DNA, with eDNA being required for the formation and integrity of biofilms. Here we demonstrate that the spatial and temporal release of eDNA is regulated b...
ORGANISM(S): Pseudomonas aeruginosa 
2011-06-01 | E-GEOD-28953 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of hMADS cells transfected with miR-26a and induced to differentiate into adipocytes
Human multipotent adipose-derived stem (hMADS) cells were transfected at confluence with miR-26a or miR-C (non-targeting control microRNA). Two days later (=d0), adipocyte differentiation was induced. At d9 after start of differentiation, cells were harvested to identify mRNAs that are down- and upr...
ORGANISM(S): Homo sapiens 
2013-11-25 | E-MARS-29 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of hMADS cells transfected with miR-26a
Human multipotent adipose-derived stem (hMADS) cells were transfected at confluence with miR-26a or miR-C (non-targeting control microRNA) and cells were harvested two days later (=d0) to identify mRNAs that are downregulated by miR-26a versus miR-C, as such mRNAs could be direct miR-26a targets.
ORGANISM(S): Homo sapiens 
2013-11-25 | E-MARS-28 | biostudies-arrayexpress
UnknownOlaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation.
Not available
S-EPMC6057749 | biostudies-literature
MetabolomicsDIAMetAlyzer allows automated false-discovery rate-controlled analysis for data-independent acquisition in metabolomics
The extraction of meaningful biological knowledge from high-throughput mass spectrometry data relies on limiting false discoveries to a manageable amount. For targeted approaches in metabolomics a main challenge is the detection of false positive metabolic features in the low signal-to-noise ranges ...
2022-09-05 | MTBLS1108 | MetaboLights
ProteomicsEffect of rumen-protected methionine on metabolic profile in liver, muscle and blood serum samples of growing German Simmental bulls at restricted protein supply
This study aimed to determine the metabolic response of growing Fleckvieh bulls fed diets low in crude protein (CP) supplemented with rumen-protected methionine (RPM). In total, 69 bulls were assigned to three dietary treatments (n=23/group): Positive control (CON; 13.7% CP; 2.11 g methionine/kg DM...
ORGANISM(S): Bos Taurus (ncbitaxon:9913) 
2023-07-07 | MSV000092367 | MassIVE
UnknownBioactive VEGF-C from E. coli.
Not available
S-EPMC9616921 | biostudies-literature
TranscriptomicsA gp130-induced Src/Yes-YAP Cascade Links Inflammation to Regeneration in the Mammalian Intestine
gp130Act cDNA was PCR-amplified and inserted into a plasmid containing the 12.4-kb Villin promoter. The 15.7-kb expression cassette was excised by PmeI digestion, purified, and injected into fertilized C57BL/6 oocytes to obtain founder mice, two of which transmitted the gp130Act transgene. Small int...
ORGANISM(S): Mus musculus 
2015-02-21 | E-MTAB-2400 | biostudies-arrayexpress
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