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TranscriptomicsPost-replicative formation of cohesion is required for repair and induced by a single DNA break
Sister chromatid cohesion, established during replication by the protein complex Cohesin, is essential for both chromosome segregation and double-strand break (DSB) repair. Normally cohesion formation is strictly limited to the S-phase of the cell cycle, but DSBs can trigger cohesion also after DNA ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-8270 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human umbilical vein endothelial cells treated with valproic acid
Valproic acid (VPA) is a short-chain fatty acid used in the treatment of epilepsy and also considered to be an epigenetic modifier by functioning as a histone deacetylase (HDAC)-inhibitor. The aim of this study was to search for gene altered by VPA in human endothelial cells. Human umbilical vein en...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-23909 | biostudies-arrayexpress
TranscriptomicsSystems biology approaches reveal low-dose effects of nanoparticles
Here, we show that systems biology approaches can uncover mechanisms underlying cellular responses to nanomaterials. Using RNA Seq, we found that cationic nanoparticles are capable of triggering down-regulation of cell cycle-related genes in primary human bronchial epithelial cells at doses that do ...
ORGANISM(S): Homo sapiens 
2015-01-17 | E-MTAB-2397 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human umbilical vein endothelial cells (HUVEC) exposed to sheer stress and intraluminal pressure
Intact living conduit vessels (umbilical veins) were exposed to normal or high intraluminal pressure, or low or high shear stress in combination with a physiological level of the other force. We used a unique vascular ex vivo perfusion system. After six hours of perfusion endothelial cells were isol...
ORGANISM(S): Homo sapiens 
2007-08-04 | E-GEOD-1518 | biostudies-arrayexpress
UnknownAge-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.
Not available
S-EPMC8631592 | biostudies-literature
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