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GenomicsA comprehensive epigenome map of Plasmodium falciparum reveals unique mechanisms of transcriptional regulation
Epigenetic mechanisms have been poorly understood in Plasmodium falciparum, the causative agent of malaria. To elucidate stage specific epigenetic regulations in P. falciparum, we performed genome-wide mapping of various histone modifications, nucleosomes and RNA Polymerase II. Our comprehensive ana...
ORGANISM(S): Plasmodium falciparum 
2015-09-23 | E-GEOD-63369 | biostudies-arrayexpress
GenomicsATAC and Mediator coactivators form a stable complex and regulates a set of non-coding RNA genes
The ATAC histone acetyl-transferase (HAT) and the Mediator coactivator complexes regulate independent and distinct steps during transcription initiation and elongation. Here we report the identification of a new stable molecular assembly formed between the ATAC and the Mediator complex in mouse embr...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-21717 | biostudies-arrayexpress
GenomicsSAGA and ATAC histone acetyl transferase complexes regulate distinct sets of genes and ATAC defines a class of p300-independent enhancers
Metazoan SAGA and ATAC are distinct multi-subunits complexes that share the same catalytic HAT subunit (GCN5 or PCAF). Here we show that these human HAT complexes are targeted to different genomic loci representing functionally distinct regulatory elements both at broadly expressed and tissue specif...
ORGANISM(S): Homo sapiens 
2011-11-05 | E-GEOD-31052 | biostudies-arrayexpress
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