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ProteomicsGenetic aberrations in MAP kinase pathway play an important role in erlotinib resistance in head and neck cancer
Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase is overexpressed in 90% of Head and neck squamous cell carcinoma (HNSCC) patients. Clinical trials with EGFR-targeted tyrosine kinase inhibitors such as erlotinib have shown a modest activity in HNSCC alternate mechanisms of resist...
ORGANISM(S): Homo sapiens (Human) 
2019-12-18 | PXD007785 | Pride
Head and neck cancer Mass spectrometry Signaling pathways Quantitative phosphoproteomics Egfr-tyrosine kinase inhibitor resistance 
ProteomicsSILAC-based proteomic approach to delineate molecular alterations associated with erlotinib resistance in head and neck squamous cell carcinoma
Although Epidermal growth factor receptor (EGFR) is overexpressed in 90% of Head and neck squamous cell carcinoma (HNSCC) patients. Clinical trials with EGFR-targeted small molecule inhibitors such as erlotinib have shown a modest activity in recurrent or advanced HNSCC. To investigate the acquired ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-18 | PXD007768 | Pride
Head and neck cancer Mass spectrometry Signaling pathways Quantitative proteomics Egfr-tyrosine kinase inhibitor resistance 
TranscriptomicsTranscription profiling of free-living Rhizobium leguminosarum bacteria grown on succinae ammonia AMS compared to glucose ammonia AMS
Free-living bacteria were grown on succinae ammonia AMS and gene expression was compared to free-living bacteria grown on glucose ammonia AMS.
ORGANISM(S): Rhizobium leguminosarum 
2008-11-30 | E-MEXP-1919 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of Rhizobium leguminosarum from pea nodules compared to cells grown in free-living culture on succinate ammonia AMS
Time course of bacteroid formation. Bacteroids were harvested from pea nodules at 7, 15 and 21 d after inoculation onto 7 d old pea plants. The transcription profile of each bacteroid sample at the 3 time points was compared to cells grown in free-living culture on succinate ammonia AMS.
ORGANISM(S): Rhizobium leguminosarum 
2008-11-27 | E-MEXP-1918 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Rhizobium leguminosarum biovar viciae strain 3841 inoculated onto pea seeds compared to cells grown in free-living culture on succinate ammonia AMS
Rhizobium leguminosarum bv viciae strain 3841 was inoculated onto pea (Pisum sativum) seeds and nodules were harvested at 28 d. The gene expression was compared to free-living bacteria grown on succinate ammonia AMS medium.
ORGANISM(S): Rhizobium leguminosarum 
2008-11-30 | E-MEXP-1925 | biostudies-arrayexpress
UnknownAdaptation of Rhizobium leguminosarum to pea, alfalfa and sugar beet rhizospheres investigated by comparative transcriptomics.
Not available
S-EPMC3333776 | biostudies-literature
UnknownBacA is essential for bacteroid development in nodules of galegoid, but not phaseoloid, legumes.
Not available
S-EPMC2876491 | biostudies-literature
UnknownPathway of gamma-aminobutyrate metabolism in Rhizobium leguminosarum 3841 and its role in symbiosis.
Not available
S-EPMC2655508 | biostudies-literature
UnknownProtective efficacy of Zika vaccine in AG129 mouse model.
Not available
S-EPMC5388871 | biostudies-literature
UnknownEvaluating Changes in Cell-Wall Components Associated with Clubroot Resistance Using Fourier Transform Infrared Spectroscopy and RT-PCR.
Not available
S-EPMC5666740 | biostudies-literature
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